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Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-methylbenzhydrazide is used as an intermediate in the synthesis of various pharmaceuticals for its potential role in the development of new drugs. Its potent antibacterial and antifungal properties make it a valuable component in creating medications aimed at treating infections.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Chloro-4-methylbenzhydrazide is utilized as an intermediate in the production of agrochemicals, contributing to the development of substances that help control and prevent bacterial and fungal infections in crops, thereby enhancing agricultural productivity.
Used in Organic Synthesis:
3-Chloro-4-methylbenzhydrazide is employed as a reagent in organic synthesis, facilitating various chemical reactions that lead to the formation of a wide array of organic compounds, which can be used in different industries.
Used in Materials Science:
In the field of materials science, 3-Chloro-4-methylbenzhydrazide has potential applications as a component in the production of polymers, where it can contribute to the development of materials with specific properties required for various applications.

InChI:InChI=1/C8H9ClN2O/c1-5-2-3-6(4-7(5)9)8(12)11-10/h2-4H,10H2,1H3,(H,11,12)

Upstream product

• 5162-82-3 3-chloro-4-methylbenzoic acid 
• 99500-36-4 3-chloro-4-methyl-benzoic acid ethyl ester 
• 21900-30-1 3-chloro-4-methyl-benzoyl chloride 

Relevant academic research and scientific papers

Synthesis and bioactivity of sulfide derivatives containing 1,3,4-oxadiazole and pyridine

A series of novel sulfide derivatives containing 1,3,4-oxadiazole and pyridine were synthesized, characterized, and tested for their antibacterial activity against tobacco bacterial wilt and rice bacterial blight and for insecticidal activity toward diamondback moth. The results showed that some compounds had good insecticidal and bactericidal activity, e.g., the activities of compounds 6e and 6g–6j toward tobacco bacterial wilt were much better than those of commercial thiodiazole-copper, and some of the synthesized compounds possessed good insecticidal activity against Plutella xylostella. Compounds 6d, 6h, 6j, 6l, 6p, 6r, and 6p displayed over 93% activity at 500 mg L? 1.

Design, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety

A series of trifluoromethyl pyridine derivatives containing 1,3,4-oxadiazole moiety was designed, synthesized and bio-assayed for their insecticidal activity. The result of bio-assays indicated the synthesized compounds exhibited good insecticidal activity against Mythimna separata and Plutella xylostella, most of the title compounds show 100% insecticidal activity at 500 mg L-1 and >80% activity at 250 mg L-1 against the two pests. Compounds E18 and E27 showed LC50 values of 38.5 and 30.8 mg L-1 against Mythimna separata, respectively, which were close to that of avermectin (29.6 mg L-1); compounds E5, E6, E9, E10, E15, E25, E26, and E27 showed 100% activity at 250 mg L-1, which were better than chlorpyrifos (87%). CoMFA and CoMSIA models with good predictability were proposed, which revealed the electron-withdrawing groups with an appropriate bulk at 2- and 4-positions of benzene ring could enhance insecticidal activity.

Synthesis of 5-substituted-3H-[1,3,4]-oxadiazol-2-one derivatives: A carbon dioxide route (CDR)

A carbon dioxide route (CDR) for making biologically important 5-substituted-3H-[1,3,4]-oxadiazol-2-ones (SHOs) has been accomplished through synthesis and cyclization of a variety of hydrazides as the key intermediates. All of these hydrazides were prepared readily in 89-97% yields by reacting acid chlorides with a hydrazine monohydrate in the initial step. Then, SHOs were obtained in high yields from hydrazides by reacting them with carbon dioxide under basic conditions. More notable than the high yields, is that the present CDR process for the first time has succeeded in providing a straightforward cyclization reaction leading to SHO formation with simple reagents in ethanol solution.