7221-41-2

Upstream product

• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 100-39-0 benzyl bromide 

Downstream Products

• 94520-78-2 N-(2-hydroxyethyl)-N-(2-methylbenzyl)methylamine 
• 1448798-75-1 2-[benzyl(dimethyl)ammonio]ethyl hexadecyl phosphate 
• 1450663-85-0 C₂₅H₄₆NO₄P 
• 1450663-86-1 C₂₉H₅₄NO₄P 
• 1448798-78-4 2-[benzyl(dimethyl)ammonio]ethyl 2-[(2,2,4,4-tetramethylpentane-2-yl)oxy]ethyl phosphate 

Relevant academic research and scientific papers

Synthesis and antifungal activities of miltefosine analogs

Miltefosine is an alkylphosphocholine that shows broad-spectrum in vitro antifungal activities and limited in vivo efficacy in mouse models of cryptococcosis. To further explore the potential of this class of compounds for the treatment of systemic mycose

Synthesis, self-aggregation and biological properties of alkylphosphocholine and alkylphosphohomocholine derivatives of cetyltrimethylammonium bromide, cetylpyridinium bromide, benzalkonium bromide (C16) and benzethonium chloride

A series of alkylphosphocholine and alkylphosphohomocholine derivatives of cetyltrimethylammonium bromide, cetylpyridinium bromide, benzalkonium bromide (C16) and benzethonium chloride have been synthesized. Their physicochemical properties were also investigated. The critical micelle concentration (cmc), the surface tension value at the cmc (γcmc), and the surface area at the surface saturation per head group (Acmc) were determined by means of surface tension measurements. The prepared compounds exhibit significant cytotoxic, antifungal and antiprotozoal activities. Alkylphosphocholines and alkylphosphohomocholines possess higher antifungal activity against Candida albicans in comparison with quaternary ammonium compounds in general. However, quaternary ammonium compounds exhibit significantly higher activity against human tumor cells and pathogenic free-living amoebae Acanthamoeba lugdunensis and Acanthamoeba quina compared to alkylphosphocholines. The relationship between structure, physicochemical properties and biological activity of the tested compounds is discussed.

FIRE RESISTANT GLAZINGS

An additive for alkali metal silicate solutions, comprising a quaternary ammonium compound having the general formula (1) R1R2R3R4N+OH?, wherein R1, R2, R3 and R4 which may be the same or different represent alkyl groups, hydroxy-substituted alkyl groups, alkaryl groups, hydroxy-substituted alkaryl groups comprising from 1 to 12 carbon atoms, or groups having the general formula —[CH2]n-N+R5R6R7 wherein n is an integer having a value of from 1 to 12, the group —[CH2]n may be hydroxy-substituted, and R5, R6 and R7 which may be the same or different represent alkyl groups, hydroxy-substituted alkyl groups, alkaryl groups or hydroxy-substituted alkaryl groups comprising from 1 to 12 carbon atoms; with the proviso that at least one of the groups R1, R2, R3, R4, R5, R6 and R7 represents a hydroxy-substituted alkyl group or a hydroxy-substituted alkaryl group comprising at least 2 carbon atoms wherein the hydroxy substituent is not located on a carbon atom which is bonded to a nitrogen atom.