72215-93-1Relevant academic research and scientific papers
Synthesis of a radiotracer for studying σ receptors in vivo using PET: (+)-N-[11C]-benzyl-N-normetazocine (1S,5S,9S-(+)-cis-2-[11C]-benzyl-2'-hydroxy-5,9-dimethyl-6,7-benzomo rphan)
Musachio,Mathews,Ravert,Carroll,Dannals
, p. 49 - 57 (1994)
(+)-N-[11C]-Benzyl-N-normetazocine (1S,5S,9S-(+)-cis-2-[11C]-benzyl-2'-hydroxy-5,9-dimethyl-6,7-benzomo rphan), a potent and selective ligand for the σ receptor, was prepared by N-benzylation of (+)-cis-N-normetazocine with [α-1
Reaction of 11C-benzoyl chlorides with metalloid reagents: 11C-labeling of benzyl alcohols, benzaldehydes, and phenyl ketones from [11C]CO
Roslin, Sara,Dahl, Kenneth,Nordeman, Patrik
, p. 447 - 454 (2018/05/14)
In this article, we describe the carbon-11 (11C, t1/2?=?20.4?minutes) labeling of benzyl alcohols, benzaldehydes, and ketones using an efficient 2-step synthesis in which 11C-carbon monoxide is used in an initial palladium-mediated reaction to produce 11C-benzoyl chloride as a key intermediate. In the second step, the obtained 11C-benzoyl chloride is further treated with a metalloid reagent to furnish the final 11C-labeled product. Benzyl alcohols were obtained in moderated to high non-isolated radiochemical yields (RCY, 35%–90%) with lithium aluminum hydride or lithium aluminum deuteride as metalloid reagent. Changing the metalloid reagent to either tributyltin hydride or sodium borohydride, allowed for the reliable syntheses of 11C-benzaldehydes in RCYs ranging from 58% to 95%. Finally, sodium tetraphenylborate were utilized to obtain 11C-phenyl ketones in high RCYs (77%–95%). The developed method provides a new and efficient route to 3 different classes of compounds starting from aryl iodides or aryl bromides.
Improved synthesis and application of [11C]benzyl iodide in positron emission tomography radiotracer production
Peko?ak, Aleksandra,Filp, Ulrike,Rotteveel, Lonneke,Poot, Alex J.,Windhorst, Albert D.
, p. 342 - 348 (2015/08/03)
Positron emission tomography has increased the demand for new carbon-11 radiolabeled tracers and building blocks. A promising radiolabeling synthon is [11C]benzyl iodide ([11C]BnI), because the benzyl group is a widely present functi
Synthesis of -labelled Aldehydes
Halldin, C.,Langstroem, B.
, p. 1 - 4 (2007/10/02)
The synthesis of benzaldehyde, anisaldehyde, 4-tert-butoxybenzaldehyde, veratraldehyde, piperonal and phenylacetaldehyde labelled with 11C (t1/2=20.3 min) in the 1-position is reported.
