Synthesis of a radiotracer for studying σ receptors in vivo using PET: (+)-N-[11C]-benzyl-N-normetazocine (1S,5S,9S-(+)-cis-2-[11C]-benzyl-2'-hydroxy-5,9-dimethyl-6,7-benzomo rphan)

Article abstract of DOI:10.1002/jlcr.2580340107

(+)-N-[¹¹C]-Benzyl-N-normetazocine (1S,5S,9S-(+)-cis-2-[¹¹C]-benzyl-2'-hydroxy-5,9-dimethyl-6,7-benzomo rphan), a potent and selective ligand for the σ receptor, was prepared by N-benzylation of (+)-cis-N-normetazocine with [α-¹