72223-78-0

Upstream product

• 103-16-2 4-Benzyloxyphenol 
• 86955-02-4 (2S)-N-(1-methylethyl)-N-(methylsulfonyl)oxiranemethanamine 
• 68430-26-2 [2S]-O-isopropylidene-3-isopropylamino-1,2-propanediol 
• 72223-71-3 (2S)-3-<(1-methylethyl)(methylsulfonyl)amino>-1,2-propanediol 
• 86955-01-3 Acetic acid (S)-1-chloromethyl-2-(isopropyl-methanesulfonyl-amino)-ethyl ester 
• 72223-74-6 N-Isopropyl-N-((S)-2-methoxy-2-methyl-[1,3]dioxolan-4-ylmethyl)-methanesulfonamide 
• 72223-70-2 (4S)-2,2-dimethyl-4-<<(1-methylethyl)(methylsulfonyl)amino>methyl>-1,3-dioxolane 

Downstream Products

• 57526-82-6 (2S)-1-<4-(benzyloxy)phenoxy>-3-<(1-methylethyl)amino>-2-propanol 
• 86955-41-1 (S)-1-(4-{20-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-icosyloxy}-phenoxy)-3-isopropylamino-propan-2-ol 
• 86955-39-7 (S)-1-(4-{14-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-tetradecyloxy}-phenoxy)-3-isopropylamino-propan-2-ol 
• 86955-37-5 (S)-1-(4-{12-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-dodecyloxy}-phenoxy)-3-isopropylamino-propan-2-ol 
• 86955-43-3 (S)-1-{4-[2-(2-{2-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-phenoxy}-3-isopropylamino-propan-2-ol 
• 86955-35-3 (S)-1-(4-{10-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-decyloxy}-phenoxy)-3-isopropylamino-propan-2-ol 
• 86955-34-2 (S)-1-(4-{8-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-octyloxy}-phenoxy)-3-isopropylamino-propan-2-ol 
• 86901-76-0 (S)-1-[4-(2-{2-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-ethoxy}-ethoxy)-phenoxy]-3-isopropylamino-propan-2-ol 
• 86955-32-0 (S)-1-(4-{6-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-hexyloxy}-phenoxy)-3-isopropylamino-propan-2-ol 
• 57526-81-5 prenalterol 
• 86955-59-1 N-{(S)-2-Hydroxy-3-[4-(10-{4-[(S)-2-hydroxy-3-(isopropyl-methanesulfonyl-amino)-propoxy]-phenoxy}-decyloxy)-phenoxy]-propyl}-N-isopropyl-methanesulfonamide 
• 86955-65-9 N-((S)-2-Hydroxy-3-{4-[2-(2-{4-[(S)-2-hydroxy-3-(isopropyl-methanesulfonyl-amino)-propoxy]-phenoxy}-ethoxy)-ethoxy]-phenoxy}-propyl)-N-isopropyl-methanesulfonamide 
• 86955-56-8 (S,S)-1,1'-<1,6-hexanediylbis(oxy)bis(1,4-phenylenoxy)>bis<3-<(1-methylethyl)(methylsulfonyl)amino>-2-propanol> 
• 86955-28-4 (S)-1-(4-{2-[2-(2-{2-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-phenoxy)-3-isopropylamino-propan-2-ol 

Relevant academic research and scientific papers

Substituted (10H-phenothiazin-10-L)-propyl-1-piperazines

Substituted (10H-phenothiazin-10-yl)propyl-1-piperazines of the formula STR1 wherein R1, R2, R3, A, X, m, n and s are as hereinafter set forth, are described. The compounds of formula I, which contain a piperazine moiety combined by an ether linkage to different phenolic moieties, are useful as orally active long lasting antipsychotic agents.

β1-Selective Adrenoceptor Antagonists. 1. Synthesis and β-Adrenergic Blocking Activity of a Series of Binary (Aryloxy)propanolamines

A series of binary (aryloxy)propanolamines has been prepared and examined in vitro and in vivo for β-adrenoreceptor blocking activity.These symmetrical compounds consist of two (S)-(phenyloxy)propanolamine pharmacophores coupled through alkylenedioxy or poly(oxyethylenedioxy) linking units of varying lengths.Examples of such binary compounds linked through the 2,2', 3,3', and 4,4' positions in the aromatic rings of the pharmacophores have been prepared.In vitro and in vivo test data indicate that the 2,2' compounds tend to be selective β2-adrenergic blocking agents, the 4,4' binaries tend to be selective β1-blocking agents, and those compounds with 3,3' linkages exhibit intermediate selectivities.One of the 4,4'-linked binary compounds, 4s, exhibited potent, cardioselective β-blockade in vivo, which was of short duration and was accompanied by a prolonged tachycardia.