72223-82-6Relevant academic research and scientific papers
Spiro[pyrrolidine-3,3′-oxindoles] as 5-HT7 receptor ligands
Kelemen, ádám Andor,Sata?a, Grzegorz,Bojarski, Andrzej J.,Keser?, Gy?rgy M.
, p. 2418 - 2421 (2018)
Here we report the design and synthesis of spiro[pyrrolidine-3,3′-oxindole] derivatives representing a novel scaffold of 5-HT7 receptor ligands. The synthesized analogues were validated as low nanomolar ligands showing selectivity in a panel of
Synthesis of a novel series of 4-arylpiperazinyl derivatives linked to a 2-(Pyridin-3-yl)-1H-benzimidazole as new delavirdine analogues
Pessoa-Mahana, David,Nu?n?ez, Andre?s,Espinosa, Christian,Mella-Raipa?n, Jaime,Pessoa-Mahana, Herna?n
experimental part, p. 63 - 70 (2010/08/20)
The synthesis of a series of substituted arylpiperazines linked to a 2-(pyridin-3-yl)-1H-benzo[d] imidazole scaffold through an alkylic linker is reported. The novel 1-(2-(4-arylpiperazin-1-yl) alkyl)-2-(pyridin-3-yl)-1H- benzimidazole derivatives are structurally related to the anti-HIV-1 drug Delavirdine and belong to the bis(heteroaryl)piperazines family (BHAPs), a well known HIV-1 reverse transcriptase inhibitors group.
