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β-(N-Methyl-2-lithio-3-indolyl)styrene is a complex organic compound that combines elements of both indole and styrene structures. It features a styrene backbone, which is a vinylbenzene molecule, with a lithium atom attached to the 2-position of the indole ring. The indole ring itself is substituted with a methyl group at the nitrogen atom and a lithium atom at the 2-position, which is adjacent to the benzene ring. β-(N-Methyl-2-lithio-3-indolyl)styrene is of interest in organic synthesis due to its potential applications in the formation of various indole-based compounds, which are prevalent in pharmaceuticals and natural products. The presence of the lithium atom makes it a reactive species, often used as an intermediate in cross-coupling reactions to form carbon-carbon or carbon-heteroatom bonds.

72228-38-7

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72228-38-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 72228-38-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,2,2 and 8 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 72228-38:
(7*7)+(6*2)+(5*2)+(4*2)+(3*8)+(2*3)+(1*8)=117
117 % 10 = 7
So 72228-38-7 is a valid CAS Registry Number.

72228-38-7Relevant academic research and scientific papers

α-Lithio-3-indolylacetate Synthons: Generation and Synthetic Utilization

Adam, Waldemar,Takayama, Kiyoshige

, p. 447 - 452 (1980)

3-Indolyl-, (N-methyl-3-indolyl)-, and (N-methyl-2-methyl-3-indolyl)acetic acids are quantitatively α-lithiated directly with n-BuLi, while methyl (N-methyl-3-indolyl)acetate is quantitatively α-lithiated with lithium diisopropylamide (LDA) at -78 deg C in THF.These useful synthons react readily with electrophiles such as alkyl halides, chlorosilanes, and ketones to afford the respective α-alkyl derivatives 1, ketene silyl acetals 2, and β-hydroxy acids 3.Photosensitized oxygenation of the ketene silyl acetals 2 affords 1,2-diox-4-ene products through (2 + 4) cycloaddition with singlet oxygen.

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