72239-34-0Relevant academic research and scientific papers
Selective Alpha 2B/2C Agonists
-
Page/Page column 11, (2011/02/25)
Described herein are compounds useful as agonists of alpha 2B/2C receptors. Pharmaceutical compositions including the presently described compounds and methods of treatment of diseases and conditions with the presently described compounds also are disclos
Synthesis and Octopaminergic Agonist Activity of 2-(Substituted benzylamino)-2-thiazolines
Hirashima, Akinori,Yoshii, Yutaka,Eto, Morifusa
, p. 1062 - 1065 (2007/10/02)
2-(Substituted benzylamino)-2-thiazolines (SBAT) were synthesized by a hydrochloric acid-catalyzed cyclization of the corresponding thioureas, using a reaction of 2-methylthio-2-thiazoline with substituted benzylamines or by alkylating 2-amino-2-thiazoline. 2-(Alkylthio)-2-thiazolines were obtained by alkylating 2-mercaptothiazoline.Most of the SBAT compounds activated adenylate cyclase in homogenates of cockroach ventral nerve cords; the effect of introducing substituents at the phenyl of the SBAT compounds on octopaminergic agonist activity was not significant. 2--2-thiazolines and 2-(alkylthio)-2-thiazolines were not significant octopaminergic agonists.Washing removed nearly all of the activity of one of the SBAT compounds, suggesting that the SBAT compounds bound reversibly to the octopaminergic receptor.
2-Aminothiazoline derivatives. Relationships between structure and antiinflammatory activity
Viallet,Boucherle,Cohen-Addad
, p. 553 - 559 (2007/10/05)
Pharmacological studies of 2-aminothiazoline amide and amine derivatives show these compounds to be actively anti-inflammatory. The structure determination by spectroscopic methods and X-ray diffraction indicates a relation between the structure and the activity of these compounds.
