722534-91-0

Upstream product

• 233587-68-3 methyl (ethyl 2,3,4-tri-O-acetyl-1-thio-D-glucopyranosid)uronate 
• 7355-18-2 (2S,3S,4S,5R,6S)-3,4,5,6-Tetraacetoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 100-39-0 benzyl bromide 

Downstream Products

• 125474-14-8 benzyl 2,3,4-tri-O-benzyl-β-D-glucopyranuronate 
• 125474-13-7 benzyl 2,3,4-tri-O-benzyl-α-D-glucopyranuronate 

Relevant academic research and scientific papers

Synthesis of urine drug metabolites: Glucuronosyl esters of carboxymefloquine, indoprofen, (S)-naproxen, and desmethyl (S)-naproxen

A general procedure for the synthesis of 1-O-acyl-β-D-glucuronic acids using the benzyl 1-O-trichloroacetimidoyl-2,3,4-tri-O-benzyl-D- glucopyranuronate 6 as donor is exemplified by the synthesis of the urine metabolites of (S)-naproxen, desmethyl (S)-naproxen, indoprofen, and carboxymefloquine. The key intermediate benzyl 2,3,4-tri-O-benzyl-D- glucopyranuronate 5 is easily accessible in four steps (29%) from the peracetylated β-D-glucuronic acid 1. Copyright