72265-42-0Relevant academic research and scientific papers
Facile α-deprotunation-electrophilic substitution of quinuclidine and DABCO
Kessar, Satinder V.,Singh, Paramjit,Singh, Kamal N.,Singh, Sandeep K.
, p. 1927 - 1928 (2007/10/03)
Deprotonation of BF3 complexes of quinuclidine or DABCO by Schlosser base and subsequent reaction with electrophiles affords α-substituted products in moderate to good yields.
Mono- and diaryl-2-quinuclidinylcarbinols with local anesthetic and antiarrhythmic activity
Nelson,Strosberg,Untch
, p. 180 - 184 (2007/10/02)
The reaction between 2-carboethoxyquinuclidine and various aryl- and heteroaryllithium reagents gave mixtures of aryl 2-quinuclidinyl ketones and diaryl-2-quinuclidinylcarbinols. Diborane reduction of the ketones gave the erythro-carbinols, stereochemically analogous to quinidine. Several of the mono- and diarylcarbinols exhibited potent local anesthetic and antiarrhythmic activity, in some cases greater than that of quinidine. Diphenyl-2-quinuclidinylcarbinol and a (bromomethoxyphenyl)(methoxyphenyl)-2-quinuclidinylcarbinol were particularly active in reverting ouabain-induced arrhythmia in dogs, showing a potency and duration of action equal to or greater than that of propranolol.
