7228-35-5Relevant academic research and scientific papers
The Winding Road towards an Atropo-enantioselective ‘ARYNE Coupling’
Augros, David,Comoy, Corinne,Fort, Yves,Leroux, Frédéric R.,Panossian, Armen
, p. 1971 - 1978 (2021)
For the first time, the challenging atropo-enantioselective coupling of in-situ generated arynes and aryllithiums in the presence of a chiral ligand of lithium was investigated. This preliminary study demonstrates the feasibility of this concept, by affording enantioenriched axially chiral biaryls even in the case of products showing a high degree of steric congestion around the newly created aryl?aryl bond.
Synthesis of cicerfuran, an antifungal benzofuran, and some related analogues
Aslam, Shazia N.,Stevenson, Philip C.,Phythian, Sara J.,Veitch, Nigel C.,Hall, David R.
, p. 4214 - 4226 (2007/10/03)
Routes were investigated for the synthesis of cicerfuran, a hydroxylated benzofuran from wild chickpea implicated in resistance to Fusarium wilt, and some of its analogues. A novel method is described for the synthesis of oxygenated benzofurans by epoxidation and cyclisation of 2′-hydroxystilbenes. The stilbene intermediates required could be synthesised by palladium-catalysed coupling of styrenes with mono-oxygenated aryl halides but not with di-oxygenated aryl halides. Stilbenes corresponding to the latter were synthesised by Wittig reactions.
