Sesamol methyl ether

Base Information

• Chemical Name: Sesamol methyl ether
• CAS No.: 7228-35-5
• Molecular Formula: C30H37ClI2N2PPd+2
• Molecular Weight: 152.15
• Mol file: 7228-35-5.mol

Synonyms:methyl sesamol;1,3-Benzodioxol-5-yl methyl ether;5-methoxybenzo[1,3]dioxole;1,3-Benzodioxole,5-methoxy;3,4-Methylenedioxyanisole;5-methoxybenzo[d][1,3]dioxole;5-methoxy-2H-benzo[d]1,3-dioxolene;sesamol methyl ether;4-methoxybenzo[1,3]dioxole;

Chemical Property of Sesamol methyl ether

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 22.40000
• Density: g/cm³
• LogP: 1.45910

Purity/Quality:

99.00% ^*data from raw suppliers

5-Methoxy-1,3-benzodioxole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Sesamol methyl ether

There total 2 articles about Sesamol methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-diacetoxy-1-iodobenzene (504421-93-6) + 1-ethynyl-2-methoxy-4,5-methylenedioxybenzene (673477-43-5) → 5-methoxybenzo[d]1,3-dioxole (7228-35-5) + Resorcinol diacetate (108-58-7) + 6-(2'-(2'',4''-diacetoxyphenyl)ethynyl)-1-methoxy-3,4-methylenedioxybenzene (673477-44-6)

Guidance literature:

With copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

DOI:10.1016/j.tet.2006.02.015

Reference yield:

1-Bromo-2-iodobenzene (583-55-1) + 4-iodo-5-methoxybenzo[d][1,3]dioxole → 5-methoxybenzo[d]1,3-dioxole (7228-35-5) + 4-(2-iodophenyl)-5-methoxybenzo[d][1,3]dioxole

Guidance literature:

4-iodo-5-methoxybenzo[d][1,3]dioxole; With n-butyllithium; In toluene; at 0 ℃; for 0.5h; Inert atmosphere;

1-Bromo-2-iodobenzene; In toluene; at -78 - 25 ℃; Inert atmosphere;

DOI:10.1002/ejoc.202100087

Reference yield: 97.0%

5-methoxybenzo[d]1,3-dioxole (7228-35-5) + Dichloromethyl methyl ether (4885-02-3) → 2-methoxy-4,5-methylenedioxybenzaldehyde (5780-00-7)

Guidance literature:

With titanium tetrachloride; for 2h; Ambient temperature;

DOI:10.1021/jo00386a014

upstream raw materials:

2,4-diacetoxy-1-iodobenzene

1-ethynyl-2-methoxy-4,5-methylenedioxybenzene

1-Bromo-2-iodobenzene

Downstream raw materials:

1-bromo-2-methoxy-4,5-methylenedioxybenzene

2-methoxy-4,5-methylenedioxybenzaldehyde

(E)-1-(2-methoxy-4,5-methylenedioxyphenyl)-2-(2-hydroxyphenyl)ethene

1-(2-methoxy-4,5-methylenedioxyphenyl)-2-(2-hydroxyphenyl)ethene oxide

Refernces

• 1、 Aslam, Shazia N.,Stevenson, Philip C.,Phythian, Sara J.,Veitch, Nigel C.,Hall, David R.. "Synthesis of cicerfuran, an antifungal benzofuran, and some related analogues". . p. 4214 - 4226. Retrieved 2007/10/03.