723263-52-3

Upstream product

• 62-53-3 aniline 
• 723262-95-1 (S)-6,6-dimethyl-5-phenyl-5,6-dihydro[1,4]oxazin-2-one 
• 6591-61-3 (S)-Phenylglycine methyl ester 
• 110480-86-9 (1S)-1-amino-2-methyl-1-phenylpropan-2-ol 
• 723263-00-1 (S)-(2-hydroxy-2-methyl-1-phenylpropyl)carbamic acid tert-butyl ester 
• 143978-88-5 N-tert-butoxycarbonyl-L-phenylglycine methyl ester 

Downstream Products

• 723263-95-4 (3S,5S)-3-[4-(benzoylamino)phenyl]-6,6-dimethyl-5-phenylmorpholin-2-one 
• 723264-01-5 N-{4-[(S)-benzylcarbamoyl(benzylideneamino)methyl]phenyl}benzamide 
• 723263-98-7 N-{4-[(S)-benzylcarbamoyl-(S-2-hydroxy-2-methyl-1-phenylpropylamino)methyl]phenyl}benzamide 

Relevant academic research and scientific papers

Stereoselective nucleophilic addition with a new chiral template and its application to the synthesis of optically active α-arylglycine derivatives

Mannich-type reaction of phenols with iminolactone 4, readily prepared from commercially available phenylglycine, proceeded with high stereoselectivity to give α-arylglycine derivatives. The reaction was also applicable to other electron-rich aromatic compounds, arylboronic acids and other nucleophiles. Additionally, several Lewis acid-promoted addition reactions with iminolactone 4 were accomplished efficiently. These adducts could be converted readily to the corresponding optically active α-amino acid derivatives.