110480-86-9

Basic information

• Product Name: (1S)-1-Amino-2-methyl-1-phenylpropan-2-ol
• Synonyms: (1S)-1-Amino-2-methyl-1-phenylpropan-2-ol;(S)-1-aMino-2-Methyl-1-phenylpropan-2-ol;1-Amino-2-methyl-1-phenylpropan-2-ol hydrochloride
• CAS NO: 110480-86-9
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.234
• Mol File: 110480-86-9.mol
• Article Data: 16

Chemical Properties

• Melting Point: 47-50℃
• Boiling Point: 295 °C at 760 mmHg
• Flash Point: 132.2 °C
• Appearance: /
• Density: 1.050
• PKA: 12.65±0.50(Predicted)
• CAS DataBase Reference: (1S)-1-Amino-2-methyl-1-phenylpropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-1-Amino-2-methyl-1-phenylpropan-2-ol(110480-86-9)
• EPA Substance Registry System: (1S)-1-Amino-2-methyl-1-phenylpropan-2-ol(110480-86-9)

Safety Data

• Hazardous Substances Data: 110480-86-9(Hazardous Substances Data)

Usage

Uses

(1S)-1-Amino-2-methyl-1-phenylpropan-2-ol can be used as reactant/reagent in stereoselective preparation of diaryl carbonyl compounds via palladium-catalyzed enantioselective redox-relay oxidative Heck arylation of arylboronic acids and homoallylic alcohols.

InChI:InChI=1S/C10H15NO/c1-10(2,12)9(11)8-6-4-3-5-7-8/h3-7,9,12H,11H2,1-2H3/t9-/m0/s1

Upstream product

• 15028-39-4 L-2-phenylglycine methyl ester hydrochloride 
• 74-88-4 methyl iodide 
• 75-16-1 methylmagnesium bromide 
• 13226-98-7 methyl (S)-2-amino-2-phenylacetate hydrochloride 
• 6591-61-3 (S)-Phenylglycine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2935-35-5 (S)-2-phenylglycine 
• 145513-97-9 (S)-(+)-2-phenyl-N-(trifluoroacetyl)glycine methyl ester 
• 143978-88-5 N-tert-butoxycarbonyl-L-phenylglycine methyl ester 
• 723263-00-1 (S)-(2-hydroxy-2-methyl-1-phenylpropyl)carbamic acid tert-butyl ester 
• 145439-97-0 (S)-2,2,2-trifluoro-N-[2-hydroxy-2-methyl-1-phenylpropyl]acetamide 

Downstream Products

• 168297-84-5 (4S)-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one 
• 1456506-81-2 (S)-5,5-dimethyl-3-(4-oxocyclohexyl)-4-phenyloxazolidin-2-one 
• 1456506-71-0 4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate 
• 1456506-76-5 (S)-3-((1r,4S)-4-(6-aminopyridin-3-yl)cyclohexyl)-5,5-dimethyl-4-phenyloxazolidin-2-one 
• 1456506-94-7 (S)-3-((1r,4R)-4-(6-amino-5-bromopyridin-3-yl)cyclohexyl)-5,5-dimethyl-4-phenyloxazolidin-2-one 
• 1456505-57-9 2-amino-5-((1S,4r)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohexyl)nicotinonitrile 
• 1588976-14-0 (S)-1-(2-hydroxy-2-methyl-1-phenylpropyl)urea 

Relevant articles and documents

Pd-Catalyzed Asymmetric Synthesis of 3,4-Dihydroisoquinolinones From N-Ts-Benzamides and 1,3-Dienes

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Catalytic Asymmetric Intermolecular Cyclopropanation of a Ketone Carbene Precursor by a Ruthenium(II)-Pheox Complex

The diazo derivative of acetonyl acetate is a useful basic skeleton for the synthesis of cyclopropyl ketones. The intermolecular cyclopropanations of diazo acetoxy acetone with olefins are accomplished by using a novel p-nitro-Ru(II)-diphenyl-Pheox catalyst to give the corresponding optically active cyclopropane derivatives in good yields (up to 95%) with excellent diastereoselectivities (up to 99:1) and enantioselectivities (up to 98% ee). (Figure presented.).

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