723294-75-5

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-5-iodobenzonitrile is used as an intermediate in the production of various pharmaceuticals for its ability to facilitate the synthesis of complex organic molecules. Its unique functional groups and reactivity in chemical reactions contribute to the development of new drugs and other useful compounds.
Used in Agrochemical Industry:
3-Fluoro-5-iodobenzonitrile is also utilized as an intermediate in the production of agrochemicals, where its versatility in organic synthesis aids in the creation of effective and novel agrochemical products.
Used in the Synthesis of Fine Chemicals:
In the realm of fine chemicals, 3-Fluoro-5-iodobenzonitrile is employed as a key intermediate, leveraging its chemical properties to synthesize high-quality specialty chemicals for various applications.

InChI:InChI=1/C7H3FIN/c8-6-1-5(4-10)2-7(9)3-6/h1-3H

Upstream product

• 210992-28-2 3-amino-5-fluoro-benzonitrile 

Downstream Products

• 1262778-27-7 3-[(2-aminothiazol-4-yl)ethynyl]-5-fluorobenzonitrile 
• 1262778-31-3 3-((2-chlorothiazol)-4-ylethynyl)-5-fluorobenzonitrile 
• 1262778-34-6 3-((2-bromothiazol-4-yl)ethynyl)-5-fluorobenzonitrile 
• 1262778-38-0 3-((2-iodothiazol-4-yl)ethynyl)-5-fluorobenzonitrile 
• 1262778-42-6 3-((2-fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrile 
• 1262778-47-1 3-((2-chlorothiazol)-4-ylethynyl)-5-fluorobenzonitrile 
• 1262778-46-0 3-((2-fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrile 

Relevant academic research and scientific papers

Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging

The structure of the potent selective mGlu5 ligand, SP203 (1, 3-fluoro-5-[[2-(fluoromethyr)thiazol-4-yl]ethynyl]benzonitrile), was modified by replacing the 2-fluoromethyl substituent with an amino or halo substituent and by variation of substituents in the distal aromatic ring to provide a series of new high-affinity mGlu5 ligands. In this series, among the most potent ligands obtained, the 2-chloro-thiazoles 7a and 7b and the 2-fluorothiazole 10b showed subnanomolar mGlu5 affinity. 10b also displayed >10000-fold selectivity over all other metabotropic receptor subtypes plus a wide range of other receptors and binding sites. The 2-fluorothiazoles 10a and 10b were labeled using [18F]fluoride ion (t1/2 = 109.7 minin moderately high radiochemical yield to provide potential radioligands that may resist troublesome radiodefluorination during the imaging of brain mGlu 5 with position emission tomography. The iodo compound 9b has nanomolar affinity for mGlu5 and may also serve as a lead to a potential 123I-labeled ligand for imaging brain mGlu5 with single photon emission computed tomography.