72332-17-3

Basic information

• Product Name: p-TFO^(1-)
• Synonyms: p-TFO^(1-)
• CAS NO: 72332-17-3
• Molecular Weight: 161.103
• Mol File: 72332-17-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: p-TFO^(1-)(CAS DataBase Reference)
• NIST Chemistry Reference: p-TFO^(1-)(72332-17-3)
• EPA Substance Registry System: p-TFO^(1-)(72332-17-3)

Safety Data

• Hazardous Substances Data: 72332-17-3(Hazardous Substances Data)

Upstream product

• 37903-93-8 4-(trifluoromethyl)phenyl methanesulfonate 
• 917-58-8 potassium ethoxide 
• 402-45-9 4-hydroxybenzotrifluoride 

Relevant articles and documents

The rate of excited-state proton transfer to solvent from trifluoromethylphenols in water

The proton-transfer reactions to solvent from electronically excited o-, m-, and p-(trifluoromethyl)phenols (TFOHs) in water have been investigated by picosecond time-resolved fluorescence measurements. The rate constants for the proton dissociation of o-, m-, and p-TFOH are obtained to be 2.2 × 10 9, 8.6 × 108, and 2.5 × 108 s -1, respectively. On the basis of the rate constants, the effects of substituent and deuterium isotope effects on the proton-transfer reactions are revealed. copyright

Nucleophilic Displacement Reactions at Carbon, Phosphorus and Sulphur Centres: Reaction of Aryl Methanesulphonates with Ethoxide; Change in Mechanism with Change in Leaving Group

The reactions of ethoxide ion with aryl methanesulphonate esters (1a-c) in anhydrous ethanol at 25 deg C have been investigated in order to determine the effect of leaving group nucleofugality on the balance between substitution and elimination pathways.The reactions of p-nitrophenyl-(1a), m-nitrophenyl-(1b) and p-trifluoromethylphenyl-(1c) methanesulphonates have been examined by means of kinetic studies, sulphene trapping experiments, and deuterium exchange experiments.It is concluded that the para-nitro-substituted ester reacts predominantly by an E1cb-type elimination mechanism via a sulphene intermediate, with nucleophilic substitution as a minor concurrent pathway.Conversely, the meta-nitro-substituted ester reacts predominantly by substitution, with elimination as a minor concurrent pathway.The evidence available indicates that the para-trifluoromethyl-substituted ester reacts solely by substitution.Thus, the mechanism of reaction changes from nucleophilic substitution to elimination-addition as leaving group nucleofugality increases.