72338-58-0

Usage

Uses

Used in Pharmaceutical Research and Development:
4-Imidazol-1-yl-butyric acid is used as a research compound for its potential therapeutic properties, particularly in the development of new drugs.
Used in Immunomodulation:
4-Imidazol-1-yl-butyric acid is used as an immunomodulatory agent for its ability to modulate the immune response, which may have applications in treating various immune-related conditions.
Used in Anti-Inflammatory Applications:
As an anti-inflammatory agent, 4-imidazol-1-yl-butyric acid is used to reduce inflammation, which can be beneficial in managing inflammatory diseases.
Used in Neurological Disorder Treatment:
4-Imidazol-1-yl-butyric acid is used in the investigation of its role in modulating neurotransmitter levels in the brain, suggesting potential applications in the treatment of neurological disorders.
Used in Drug Development:
4-Imidazol-1-yl-butyric acid is used as a starting point or intermediate in the development of new drugs targeting immune response modulation and neurological conditions.

InChI:InChI=1/C7H10N2O2/c10-7(11)2-1-4-9-5-3-8-6-9/h3,5-6H,1-2,4H2,(H,10,11)

Upstream product

• 288-32-4 1H-imidazole 
• 96-48-0 4-butanolide 
• 72338-57-9 ethyl 4-(imidazol-1-yl)butyrate 
• 158147-49-0 4-(1-imidazolyl)butyric acid benzyl ester 

Downstream Products

• 148458-64-4 1-[3-(methoxycarbonyl)propyl]imidazole 
• 68887-65-0 5-(1H-imidazol-1-yl)pentanoic acid 
• 158147-52-5 4-(1,2,4-triazol-1-yl)butyric acid 
• 106134-46-7 N-(2,6-dimethylphenyl)-1H-imidazole-1-butanamide hydrobromide salt 
• 176645-97-9 1-(3,4-dichlorophenyl)-4-(1-(1H)-imidazolyl)-1-butanone 
• 198549-16-5 5,6-diphenyl-3-(3-imidazol-1-ylpropyl)-1,2,4-triazine 
• 198549-22-3 6,7-diphenyl-1,2,3,4-tetrahydro-1,5-naphthyridine 

Relevant academic research and scientific papers

Imidazole heterocyclic diphosphonic acid compound as well as preparation method and application thereof

The invention belongs to the field of pharmaceutical chemistry, and in particular relates to an imidazole heterocyclic diphosphonic acid compound as well as a preparation method and application thereof. The imidazole heterocyclic diphosphonic acid compound has a larger non-toxic concentration range for an osteoclast precursor, and can significantly inhibit the formation of osteoclasts at the same time; the imidazole heterocyclic diphosphonic acid compound can damage actin ring to the utmost extent, thus having an obvious inhibiting effect on the osteoclasts and further being used as an osteoclast inhibitor; the imidazole heterocyclic diphosphonic acid compound solves the problems that diphosphonate in the prior art is low in inhibiting effect on the osteoclasts, high in toxicity and large in side effects.

Preparation of 4-(azol-1-yl)butyric acids by the interaction of azoles with γ-butyrolactone

The interaction of salts of imidazole, 1,2,4-triazole, benzimidazole, and 2-benzylbenzimidazole with γ-butyrolactone has been studied. Ab initio quantum-chemical calculations showed a preference for N-alkylation on interaction of azolates with γ-butyrolac

Intramolecular inverse-electron-demand Diels-Alder reactions of imidazoles with 1,2,4-triazines: A new route to 1,2,3,4-tetrahydro-1,5-naphthyridines and related heterocycles

The intramolecular inverse-electron-demand Diels-Alder reaction between imidazoles and 1,2,4-triazines linked by a trimethylene tether from the imidazole N1 position to the triazine C3 proceed in excellent yields to produce 1,2,3,4-tetrahydro-1,5-naphthyridines. The reaction proceeds by a cycloaddition with subsequent loss of nitrogen, followed by a presumed stepwise loss of a nitrile. The analogous intramolecular cycloadditions employing a tetramethylene tether also proceeded to give 2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepines in acceptable yields. The reaction to produce the tetrahydro-1,5-naphthyridines can also be promoted with microwave irradiation.

Pharmaceutical composition containing quinoline or quinazoline derivatives

The present invention provides a pharmaceutical composition for inhibiting bone resorption or for preventing or treating osteoporosis which comprises a quinoline or quinazoine derivative as an active ingredient.

Dienophilicity of imidazole in inverse electron demand Diels-Alder reactions; intramolecular reactions with 1,2,4-triazines

Imidazole and 2-phenylimidazole undergo intramolecular cycloadditions with 1,2,4-triazines tethered between an imidazole nitrogen and the triazinyl C3 position with a trimethylene chain to produce tetrahydro-1,5-naphthyridines following loss of N2/s

Quinoline or quinazoline derivatives, their production and use

A compound represented by the general formula: STR1 wherein Y represents a nitrogen atom or C--G (G represents a carboxyl group which may be esterified); ring R is a nitrogen-containing unsaturated heterocyclic group which may be substituted or unsubstituted; each of rings A and B may have a substituent; n represents an integer from 1 to 4; k represents the integer 0 or 1, or a salt thereof, which serves well as an anti-inflammatory agent, particularly a therapeutic agent for arthritis.

REACTION OF IMIDAZOLE AND ITS 2-ALKYL DERIVATIVES WITH γ-BUTYROLACTONE

Reaction of imidazole with γ-butyrolactone gives N-alkylation and N-acylation products depending upon the reaction conditions.