7234-65-3

Basic information

• Product Name: 1,3,4,6,11,11a-hexahydro-2H-pyrido[1,2-b]isoquinoline
• Synonyms: 2H-benzo[b]quinolizine, 1,3,4,6,11,11a-hexahydro-
• CAS NO: 7234-65-3
• Molecular Formula: C₁₃H₁₇N
• Molecular Weight: 187.2808
• Mol File: 7234-65-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 288.8°C at 760 mmHg
• Flash Point: 117.3°C
• Density: 1.07g/cm³
• Vapor Pressure: 0.00229mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 1,3,4,6,11,11a-hexahydro-2H-pyrido[1,2-b]isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4,6,11,11a-hexahydro-2H-pyrido[1,2-b]isoquinoline(7234-65-3)
• EPA Substance Registry System: 1,3,4,6,11,11a-hexahydro-2H-pyrido[1,2-b]isoquinoline(7234-65-3)

Safety Data

• Hazardous Substances Data: 7234-65-3(Hazardous Substances Data)

Usage

Molecular structure

A complex structure with a hexahydro-2H-pyrido[1,2-b]isoquinoline core.

Class

Hetrocyclic compounds

Derivative

A derivative of the naturally occurring alkaloid harman.

Psychoactive properties

Known for its psychoactive properties.

Therapeutic effects

Studied for its potential therapeutic effects on the central nervous system.

Neurological disorders

Investigated for its potential role in neurological disorders.

Effects on mood, cognition, and behavior

Known to have effects on mood, cognition, and behavior.

Neurotransmitter and receptor modulation

Implicated in the modulation of various neurotransmitters and receptors in the brain.

Pharmacological research

A subject of interest for pharmacological research.

Implications

Has potential implications for neuropharmacology and neurochemistry.

Upstream product

• 15912-12-6 3,4,11,11a-tetrahydro-2H,6H-pyrido[1,2-b]isoquinolin-1-one 
• 138350-83-1 N-(tert-butoxycarbonyl)-2-methylbenzylamine 
• 155955-82-1 2-(tert-butoxycarbonyl)-3-(4-chloro-1-n-butyl)-1,2-dihydroisoquinoline 
• 138344-21-5 4-Chloro-N,O-dimethylbutyric acid amide 
• 15912-58-0 2-(3-ethoxycarbonyl-propyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ethyl ester 
• 89-93-0 ortho-methylbenzylamine 
• 184356-09-0 [2-(Diphenyl-phosphinoyl)-piperidin-1-yl]-phenyl-methanone 
• 184356-17-0 (2-Methylene-piperidin-1-yl)-phenyl-methanone 
• 175857-65-5 2-(diphenylphosphinoyl)piperidine 
• 522-33-8 Tripiperidin 
• 2563-84-0 3-phenylhexahydro-1H-oxazolo[3,4-a]pyridine 
• 137650-02-3 (1-benzylpiperidin-2-yl)methanol 
• 7803-57-8 hydrazine hydrate 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 

Relevant articles and documents

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Diastereoselective electrophilic substitution of α-amino-substituted benzylic organometallics

Reductive metallation of a diastereoisomeric bicyclic 2-phenyloxazolidine derived from 2-hydroxymethylpiperidine occurs with racemization at the benzylic carbon atom. Reaction of intermediate organometallics with alkyl halides affords substituted amino alcohols in a highly syn-selective fashion. Observed diastereoselectivities are rationalized in terms of rapidly equilibrating epimeric intermediate organometallics, one of which reacts preferentially under appropriate reaction conditions. Deuteration of the same intermediates usually leads to deuterated amino alcohols with low diasteroselectivities, unless lithium is employed as the reducing agent and the resulting mixture is allowed to equilibrate before deuteration.

Heteroatom-directed lateral lithiation: Synthesis of isoquinoline derivatives from N-(tert-butoxycarbonyl)-2-methylbenzylamines

Methodology for the preparation of isoquinoline derivatives from N-(tert-butoxycarbonyl)-2-methylbenzylamines (1) was developed. Conversion of 1 to the dilithio species followed by condensation with DMF afforded Boc-3-hydroxy-1,2,3,4-tetrahydroisoquinolin