72342-55-3Relevant academic research and scientific papers
Transition-Metal-Free Synthesis of Acridones via Base-Mediated Intramolecular Oxidative C?H Amination
Wei, Wen-Tao,Sheng, Jian-Fei,Miao, Hui,Luo, Xiang,Song, Xian-Heng,Yan, Ming,Zou, Yong
supporting information, p. 2101 - 2106 (2018/06/14)
Intramolecular oxidative C?H amination of 2-aminobenzophenones was achieved in the presence of potassium tert-butoxide and dimethyl sulfoxide. A series of functionalized acridones were prepared in moderate to excellent yields in a mild, efficient, and transition-metal-free manner. (Figure presented.).
Palladium-catalyzed oxidative C-H bond acylation of N-nitrosoanilines with toluene derivatives: A traceless approach to synthesize N-alkyl-2-aminobenzophenones
Wu, Yinuo,Feng, Ling-Jun,Lu, Xiao,Kwong, Fuk Yee,Luo, Hai-Bin
, p. 15352 - 15354 (2015/01/08)
A palladium-catalyzed cascade cross-coupling of N-nitroso-anilines and toluene derivatives for the direct synthesis of N-alkyl-2-aminobenzophenones is described. N-nitroso groups in anilines can act as the traceless directing groups while toluene derivatives can serve as effective acyl precursors under mild reaction conditions.
New methodology for the N-alkylation of 2-amino-3-acylthiophenes
Aurelio, Luigi,Flynn, Bernard L.,Scammells, Peter J.
experimental part, p. 4886 - 4902 (2011/08/06)
2-Amino-3-acylthiophenes are known to allosterically modulate the A 1 adenosine receptor and are also used as intermediates in the synthesis of therapeutic agents and pharmacophores such as thienoazepines and thienopyrimidines. The N-alkylation
Amide Ion Formation and N-Alkylation of Aminoanthraquinones in the presence of Potassium Hydroxide in Dimethyl Sulfoxide
Arai, Sadao,Kato, Seijiro,Hida, Mitsuhiko
, p. 1458 - 1463 (2007/10/02)
Amide ions were formed by the deprotonation of the amino group of amino group of amino- and (monoalkylamino)anthroquinones in the presence of powdered potassium hydroxide in dimethyl sulfoxide (DMSO).Under a nitrogen atmosphere these amide ions changed to their radical anions.The amide ions of 1-aminoanthroquinones reacted with excess alkyl halides to yield 1-alkylaminoanthraquinones, while the N-alkylation of 2-aminoanthraquinones afforded 2-alkylaminoanthraquinones in good yields. 2-Aminobenzophenone underwent mono-N-alkylation, while 4-aminoazobenzene and p-nitroaniline underwent di-N-alkylation.It was also found that carbanion of DMSO easily attacked the carbonyl group of the (dialkylamino)anthraquinones.
