72398-89-1Relevant articles and documents
Method for synthesizing o-alkenyl phenol derivative through ring opening of benzofuran under catalysis of nickel
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Paragraph 0042; 0144-0150, (2021/07/14)
The invention belongs to the technical field of organic synthesis, and discloses a method for synthesizing an o-alkenyl phenol derivative through ring opening of benzofuran under catalysis of nickel. The method comprises the following step: in a protective atmosphere and with an organic solvent as a reaction medium, subjecting a benzofuran compound to reacting with a silicon-hydrogen compound under the action of a nickel catalyst and a ligand or the action of the nickel catalyst, the ligand and an additive to obtain a product containing a silicon protecting group, namely the o-alkenyl phenol derivative containing the silicon protecting group; or removing the silicon-containing protecting group to obtain the o-alkenyl phenol derivative, namely the o-alkenyl phenol derivative containing the phenolic hydroxyl group. According to the method, nickel is used as a catalyst, a phosphine compound or N-heterocyclic carbene is used as a ligand, and the method has the advantages of high yield, wide substrate applicability and the like. In addition, the benzofuran compound is used as a raw material in the reaction, so the method has the advantages of cheap and easily available raw materials, simplicity and convenience in operation, mild reaction conditions, good functional group position compatibility and the like, and has very high practicability.
