724-88-9

Upstream product

• 100-68-5 methyl-phenyl-thioether 
• 403-43-0 4-fluorobenzoyl chloride 
• 104-95-0 (4-bromophenyl)thioanisole 
• 456-22-4 4-Fluorobenzoic acid 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 1510-48-1 4-fluoro-4'-methylsulfanyl-benzhydrol 
• 197438-91-8 (4-Fluorophenyl)[4-(methylsulfonyl)phenyl]ketone 
• 197439-01-3 5,5-dimethyl-3-[1-(4-fluorophenyl)-1-hydroxy-1-(4-methylthiophenyl)methyl]dihydrofuran-2-one 

Relevant academic research and scientific papers

COMPOSITION AND METHOD FOR MANUFACTURING DEVICE USING SAME

An onium salt and a composition having high sensitivity and excellent pattern characteristics such as LWR, which is preferably used for a resist composition for a lithography process using two active energy rays of a first active energy ray such as an electron beam or an extreme ultraviolet and a second active energy ray such as UV.

4,5-Diaryl 3(2H)Furanones: Anti-inflammatory activity and influence on cancer growth

Apart from their anti-inflammatory action, COX inhibitors have gathered the interest of many scientists due to their potential use for the treatment and prevention of cancer. It has been shown that cyclooxygenase inhibitors restrict cancer cell growth and are able to interact with known antitumor drugs, enhancing their in vitro and in vivo cytotoxicity. The permutation of hydrophilic and hydrophobic aryl groups in COX inhibitors leads to cardinal changes in the biological activity of the compounds. In the present study, thirteen heterocyclic coxib-like 4,5-diarylfuran-3(2H)-ones and their annelated derivatives-phenanthro[9,10-b]furan-3-ones-were synthesized and studied for anti-inflammatory and COX-1/2 inhibitory action and for their cytotoxic activity on the breast cancer (MCF-7) and squamous cell carcinoma (HSC-3) cell lines. The F-derivative of the -SOMe substituted furan-3(2H)-ones exhibited the best activity (COX-1 IC50 = 2.8 μM, anti-inflammatory activity (by carrageenan paw edema model) of 54% (dose 0.01 mmol/kg), and MCF-7 and HSC-3 cytotoxicity with IC50 values of 10 μM and 7.5 μM, respectively). A cytotoxic effect related to the COX-1 inhibitory action was observed and a synergistic effect with the anti-neoplastic drugs gefitinib and 5-fluorouracil was found. A phenanthrene derivative exhibited the best synergistic effect with gefitinib.

SULFONIUM SALT, PHOTOACID GENERATOR, COMPOSITION COMPRISING THE SAME, AND DEVICE MANUFACTURING METHOD

PROBLEM TO BE SOLVED: To provide a sulfonium salt suitably used for a photoacid generator realizing a photoresist having high sensitivity and enhancing acid generation efficiency. SOLUTION: The sulfonium salt is represented by the general formula (1) in the figure. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics

The present invention relates to derivatives of the formula the process for their preparation, and to their uses in therapeutics, especially as drugs with anti-inflammatory, analgesic and chemopreventive properties.

Diarylmethylidenefuran derivatives and their uses in therapeutics

The present invention relates to the derivatives of the formula STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.

Carbocyclic diarylmethylene derivatives, processes for their preparation and their uses in therapeutics

The present invention relates to the carbocyclic diarylmethylene derivatives of formula (I): STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.