72409-43-9 Usage
Uses
Used in Pharmaceutical Industry:
Guanosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]is used as a precursor in the synthesis of modified nucleic acids and oligonucleotides for drug development. Its unique structure allows for the creation of tailored molecules with specific properties, potentially leading to the discovery of new therapeutic agents.
Used in Diagnostics Industry:
In the field of diagnostics, Guanosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]serves as a building block for the development of nucleic acid-based diagnostic tools. Its modified structure enables the design of highly specific and sensitive assays for detecting various diseases and conditions.
Used in Synthetic Chemistry:
Guanosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]is utilized as a versatile intermediate in synthetic chemistry for the preparation of complex nucleic acid structures. Its enhanced stability and selectivity facilitate the synthesis of novel compounds with potential applications in various fields, including materials science and nanotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 72409-43-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,4,0 and 9 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 72409-43:
(7*7)+(6*2)+(5*4)+(4*0)+(3*9)+(2*4)+(1*3)=119
119 % 10 = 9
So 72409-43-9 is a valid CAS Registry Number.
72409-43-9Relevant academic research and scientific papers
Aqueous trichloroacetic acid: Another useful reagent for highly selective 5′-desilylation of multisilylated nucleosides
Zhu, Xue-Feng,Williams, Howard J.,Scott, A. Ian
, p. 2011 - 2016 (2007/10/03)
Highly selective 5′-desilylation of multisilylated nucleosides can be achieved in excellent yield by treatment with 4.2 M aqueous trichloroacetic acid:THF (1:4) at 0°C.
Nucleotides, XVIII. Synthesis and Properties of (tert-Butyldimethylsilyl)guanosines, Guanosine-3'-Phosphotriesters and Guanosine-containing Oligonucleotides
Flockerzi, Dieter,Schlosser, Wilhelm,Pfleiderer, Wolfgang
, p. 2069 - 2085 (2007/10/02)
Silylation of N2-benzoyl- (1) and N2-isobutyrylguanosin (2) by tert-butyldimethylsilyl chloride led to the various mono-, di- and tri-O-tert-butyldimethylsilyl derivatives 3-15.The synthesis of 2'- (24-31) and 3'-phosphotriesters (16
ISOMERIZATION OF tert-BUTYLDIMETHYLSILYL PROTECTING GROUPS IN RIBONUCLEOSIDES
Ogilvie, Kelvin K.,Entwistle, Douglas W.
, p. 203 - 210 (2007/10/02)
The tert-butyldimethylsilyl group undergoes isomerization between O-2' and O-3' in ribonucleosides in solution.Isomerization is most rapid in protic solvents and extremely slow in such solvents as dry dimethyl sulfoxide, pyridine, oxolane, chloroform, or
