72409-44-0 Usage
Uses
Used in Organic Synthesis:
Guanosine, N-benzoyl-3'-O-[(1,1-dimethylethyl)dimethylsilyl]is used as a protected form of guanosine in organic synthesis for its ability to be selectively deprotected under specific conditions. This selective deprotection allows for the controlled release of the free guanosine molecule, enabling further reactions and the synthesis of more complex organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Guanosine, N-benzoyl-3'-O-[(1,1-dimethylethyl)dimethylsilyl]is used as an intermediate in the synthesis of nucleoside-based drugs. The protective group ensures that the guanosine molecule remains stable and unreactive during the initial stages of synthesis, facilitating the production of targeted pharmaceutical compounds with specific therapeutic properties.
Used in Chemical Research:
Guanosine, N-benzoyl-3'-O-[(1,1-dimethylethyl)dimethylsilyl]is also utilized in chemical research for studying the reactivity and properties of nucleosides. The presence of the protective group allows researchers to investigate the effects of selective deprotection on the guanosine molecule and its subsequent reactions, contributing to a deeper understanding of nucleoside chemistry and its applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 72409-44-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,4,0 and 9 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 72409-44:
(7*7)+(6*2)+(5*4)+(4*0)+(3*9)+(2*4)+(1*4)=120
120 % 10 = 0
So 72409-44-0 is a valid CAS Registry Number.
72409-44-0Relevant academic research and scientific papers
Aqueous trichloroacetic acid: Another useful reagent for highly selective 5′-desilylation of multisilylated nucleosides
Zhu, Xue-Feng,Williams, Howard J.,Scott, A. Ian
, p. 2011 - 2016 (2007/10/03)
Highly selective 5′-desilylation of multisilylated nucleosides can be achieved in excellent yield by treatment with 4.2 M aqueous trichloroacetic acid:THF (1:4) at 0°C.
Nucleotides, XVIII. Synthesis and Properties of (tert-Butyldimethylsilyl)guanosines, Guanosine-3'-Phosphotriesters and Guanosine-containing Oligonucleotides
Flockerzi, Dieter,Schlosser, Wilhelm,Pfleiderer, Wolfgang
, p. 2069 - 2085 (2007/10/02)
Silylation of N2-benzoyl- (1) and N2-isobutyrylguanosin (2) by tert-butyldimethylsilyl chloride led to the various mono-, di- and tri-O-tert-butyldimethylsilyl derivatives 3-15.The synthesis of 2'- (24-31) and 3'-phosphotriesters (16
ISOMERIZATION OF tert-BUTYLDIMETHYLSILYL PROTECTING GROUPS IN RIBONUCLEOSIDES
Ogilvie, Kelvin K.,Entwistle, Douglas W.
, p. 203 - 210 (2007/10/02)
The tert-butyldimethylsilyl group undergoes isomerization between O-2' and O-3' in ribonucleosides in solution.Isomerization is most rapid in protic solvents and extremely slow in such solvents as dry dimethyl sulfoxide, pyridine, oxolane, chloroform, or
