72410-60-7Relevant academic research and scientific papers
Biomimetic Desymmetrization of a Carboxylic Acid
Knowe, Matthew T.,Danneman, Michael W.,Sun, Sarah,Pink, Maren,Johnston, Jeffrey N.
, p. 1998 - 2001 (2018)
The enantioselective desymmetrization of carboxylic acids by chiral Br?nsted base catalysis is reported, leading to bridged bicyclic lactones with up to 94% ee. Crystallographic analysis of a substrate-catalyst complex suggests an origin of stereocontrol, reminiscent of functional Br?nsted bases in biological settings, and enabled reaction optimization. The products contain an all-carbon quaternary stereocenter and can be derivatized to functionalized cyclopentanes.
