72425-89-9

Upstream product

• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 99-61-6 3-nitro-benzaldehyde 
• 60-80-0 antipyrine 
• 885-11-0 1,5-dimethyl-4-nitroso-2-phenyl-1,2-dihydro-pyrazol-3-one 

Downstream Products

• 112907-97-8 UO₂(C₁₈H₁₆NO₂N₃O)2(NO₃)2 
• 125298-52-4 1,2-dihydro-2,3-dimethyl-4-(2-(3-nitrophenyl)-4-oxothiazolidin-3-yl)-1-phenylpyrazol-5-one 
• 134271-76-4 3,4'-dinitrochalcone 

Relevant academic research and scientific papers

Characterization of antimicrobial, antioxidant, and leishmanicidal activities of Schiff base derivatives of 4-aminoantipyrine

Our main interest is the characterization of compounds to support the development of alternatives to currently marketed drugs that are losing effectiveness due to the development of resistance. Schiff bases are promising biologically interesting compounds

Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors

In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical characterization of the compounds was confirmed using IR, 1H NMR, 13C NMR and mass spectroscopies. The inhibitory potency of synthesized compounds was investigated towards acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and monoamine oxidases A and B (MAO-A and MAO-B) enzymes. Some of the compounds displayed significant inhibitory activity against AChE and MAO-B enzymes, respectively. According to AChE enzyme inhibition assay, compounds 3e and 3g were found as the most potent derivatives with IC50 values of 0.285 μM and 0.057 μM, respectively. Also, compounds 3a (IC50 = 0.114 μM), 3h (IC50 = 0.049 μM), and 3i (IC50 = 0.054 μM) were the most active derivatives against MAO-B enzyme activity. So as to understand inhibition type, enzyme kinetics studies were carried out. Furthermore, molecular docking studies were performed to define and evaluate the interaction mechanism between compounds 3g and 3h and related enzymes. ADME (Absorption, Distribution, Metabolism, and Excretion) and BBB (Blood, Brain, Barier) permeability predictions were applied to estimate pharmacokinetic profiles of synthesized compounds.

Synthesis, characterization, and biological evaluation of Schiff base-platinum(II) complexes

The platinum complexes of Schiff base ligands derived from 4-aminoantipyrine and a few substituted aldehydes were synthesized and characterized by elemental analysis, mass, 1H NMR, IR, electronic spectra, molar conductance, and powder XRD. The

Synthesis of 4-amino-1,5-dimethyl-2-phenylpyrazolone derivatives and their antioxidant activity

Schiff bases of 4-amino-1,5-dimethyl-2-phenylpyrazolone (2-18) were synthesized by treating with different benzaldehyde derivatives and tested for in vitro antioxidant activity. Synthesized Schiff base derivatives (2-18) were characterized by various spec

Activated fly ash catalyzing the synthesis of novel potent 4-thiazolidinones of 4-amino antipyrine anils using CEM discover microwave methodology and their virtual screening

Fly ash, an industrial waste, has been used as an efficient and cost-effective activating catalyst for the synthesis of new potent thiazolidinones (4a-n), starting from imine (3a-n) and thioacetic acid. The reactions were performed under CEM Discover micr

Predictions and correlations of structure activity relationship of some aminoantipyrine derivatives on the basis of theoretical and experimental ground

A series of 4-aminoantipyrine derivatives were produced by condensing aromatic primary amine, namely, 4-aminoantipyrine with different aryl carbonyls which occurred cleanly and efficiently without using any catalyst at room temperature. Their structures w

Design, synthesis, antimicrobial, anticancer evaluation, and QSAR studies of 4-(substituted benzylidene-Amino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3- ones

A series of 4-(substituted benzylidene-Amino)-1,5-dimethyl-2-phenyl-1,2- dihydropyrazol-3-ones (1-17) was synthesized and tested in vitro for its antimicrobial and anticancer potentials. The biological screening results indicated that compounds having m-c

Brand new quantitative solid-state synthesis of N-pyrazolyl azomethines

Fifteen preparatively useful azomethines 3 and 5 have been quantitatively (100% yield at 100% conversion) obtained as hydrates by ball-milling together 4-aminoantipyrine 1 and 3-amino-4,6-dimethylpyrazolopyridine 4 with solid benzaldehydes 2 without passi

Some High Coordination Compounds of Thorium(IV) and Dioxouranium(VI) with Schiff Bases Derived from 4-Aminoantipyrine

A series of 24 new complexes of thorium(IV) and dioxouranium(VI) with Schiff's bases derived from 4-aminoantipyrine, viz. 4-antipyrine (HMBAAP), 4-antipyrine (2'-NO2BAAP) and 4-N-(3'-