724426-65-7Relevant articles and documents
2-Arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: Synthesis, binding studies and behavioral efficacy
Dubowchik, Gene M.,Michne, Jodi A.,Zuev, Dmitry,Schwartz, Wendy,Scola, Paul M.,James, Clint A.,Ruediger, Edward H.,Pin, Sokhom S.,Burris, Kevin D.,Balanda, Lynn A.,Gao, Qi,Wu, Dedong,Fung, Lawrence,Fiedler, Tracey,Browman, Kaitlin E.,Taber, Matthew T.,Zhang, Jie
, p. 3997 - 4000 (2007/10/03)
2-Arylamino-4-trifluoromethyl-5-aminomethylthiazoles represent a novel series of high-affinity corticotropin releasing factor-1 receptor (CRF 1R) antagonists that are prepared in three steps in good overall yields. Herein, we report binding SAR as well as anxiolytic activity of an exemplary compound (7a, Ki=8.6 nM) in a mouse canopy model.
