363-58-6

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-chloro-4,4,4-trifluoroacetoacetate is used as a synthetic intermediate for the preparation of furoindazole derivatives, which are GPR84 antagonists. These antagonists are useful in treating various diseases by modulating the activity of GPR84, a protein receptor that plays a role in inflammation and immune response.
Used in Organic Synthesis:
In the field of organic chemistry, Ethyl 2-chloro-4,4,4-trifluoroacetoacetate is utilized as a building block for the synthesis of a wide range of compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique functional groups allow for various chemical reactions, such as substitution, addition, and condensation, enabling the creation of diverse molecular structures with potential applications in different industries.

InChI:InChI=1/C6H6ClF3O3/c1-2-13-5(12)3(7)4(11)6(8,9)10/h3H,2H2,1H3/t3-/m1/s1

Upstream product

• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 1522-43-6 ethyl 3-oxo-4,4,4-trifluorobutanoate enol 

Downstream Products

• 431-37-8 3-chloro-1,1,1-trifluoroacetone 
• 187998-90-9 ethyl 4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate 
• 344-72-9 ethyl 2-amino-4-(trifluoromethyl)-5-thiazole-carboxylate 
• 135026-14-1 ethyl 2-[(1,1-dimethylethyl)amino]-4-trifluoromethyl-5-oxazolecarboxylate 
• 117724-63-7 2-methyl-4-trifluoromethylthiazole-5-carboxylic acid 
• 939377-14-7 ethyl 4-hydroxy-2-phenyl-4-trifluoromethyl-4,5-dihydrooxazole-5-carboxylate 
• 55942-41-1 5-trifluoromethyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 72850-52-3 ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate 
• 1253196-13-2 ethyl 3-(trifluoromethyl)pyrazine-2-carboxylate 
• 117724-62-6 ethyl 2-methyl-4-(trifluoromethyl)thiazole-5-carboxylate 
• 106203-24-1 4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester 
• 425394-36-1 5-chloro-4-hydroxy-2-methyl-6-trifluoromethylpyrimidine 

Relevant academic research and scientific papers

FUROINDAZOLE DERIVATIVES

The present invention covers furoindazole compounds of general formula (I): in which (I) are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of autoimmune diseases such as multiple sclerosis, psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, primary and secondary autoimmune uveitis, inflammatory disorders like endometriosis, inflammatory eye diseases, inflammatory kidney diseases, inflammatory liver diseases like non-alcoholic, alcoholic- and toxic fatty liver diseases, lung diseases like asthma, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and metabolic and metabolic-endocrine disorders like metabolic syndrome, insulin resistance, diabetes mellitus type I and type II, and polycystic ovary syndrome (PCOS) disorders, neuropathic and inflammatory pain disorders in humans and animals.

Chalcone compound and applications thereof

The present invention relates to a chalcone-containing compound represented by a general formula (I), and a pharmaceutically acceptable salt, a solvate and a prodrug thereof, wherein the substituentsR1, R2, R3, R4, R5, R6, Q and n have the meanings given in the specification. The invention further relates to applications of the compound represented by the general formula (I) in preparation of anti-tumor drugs, and applications of the compound and the pharmaceutically acceptable salt, solvate and prodrug thereof in preparation of drugs for preventing and/or relieving cancers caused by tumor cells of human tissues or organs, wherein the cancers are preferably colon cancer, liver cancer, lymphoma, lung cancer, esophageal cancer, breast cancer, central nervous system tumor, melanoma, skin cancer, ovarian cancer, cervical cancer, kidney cancer, leukemia, prostate cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharyngeal cancer, gastric cancer and the like.

Iodine-containing pyrazinamide compound, preparation method and applications thereof, and bactericide

The present invention relates to the field of pesticide bactericides, and discloses an iodine-containing pyrazinamide compound, a preparation method and applications thereof, and a bactericide, wherein the compound has a structure represented by a formula (I). According to the present invention, the iodine-containing pyrazinamide compound with the completely-new structure is designed by introducing the pyrazine ring of NNF-0721 and the diphenyl ether fragment having broad biological activity, and can be used as the completely-new succinate dehydrogenase inhibitor or bactericide. The formula (I) is defined in the specification.

Pyrazinamide compound, preparation method and applications thereof, and bactericide

The present invention relates to the field of pesticide bactericides, and discloses a pyrazinamide compound, a preparation method and applications thereof, and a bactericide, wherein the compound hasa structure represented by a formula (I). The preparatio

Preparation method of ethyl 2-chloro-4,4,4-trifluoroacetoacetate

The invention belongs to the technical field of pesticide chemistry and particularly relates to a preparation method of ethyl 2-chloro-4,4,4-trifluoroacetoacetate. Ethyl trifluoroacetoacetate is usedas a raw material subjected to substitution reaction with sulfonyl chloride before distilling under maintained temperature and reduced pressure is performed to obtain ethyl 2-chloro-4,4,4-trifluoroacetoacetate. A sulfur-bearing lubricant additive is used as a catalyst; reaction temperature is lowered; reaction time is shortened; the quantity of polychlorinated products is reduced; the conversion rate of ethyl trifluoroacetoacetate is >/=99%, product yield is above 93%, and the purity is above 98%.

Trifluoromethyl-containing pyrazinamide compound, preparation method and applications thereof, and bactericide

The present invention relates to the field of pesticide bactericides, and discloses a trifluoromethyl-containing pyrazinamide compound, a preparation method and applications thereof, and a bactericide, wherein the compound has a structure represented by a

Design, synthesis, insecticidal, and acaricidal activities of novel pyrimidinamine derivatives containing a biphenyl ether

A series of original pyrimidinamine derivatives containing a biphenyl ether moiety were designed and synthesized. Their structures were confirmed by 1H NMR, MS, and elemental analyses. Their insecticidal activities against lepidopteran and hemiptera insects and acaricidal activities were tested. The results of bioassay demonstrated that 9k showed the best activity (LC50 = 2.08 mg/L) against Tetranychus urticae, which is comparable with the positive control, spirotetramat (LC50 = 2.27 mg/L), and 9g showed better activity (LC50 = 0.52 mg/L) against Aphis fabae than the positive control, imidacloprid (LC50 = 1.02 mg/L), and relatively good activity (LC50 = 2.49 mg/L) against T urticae. Their structure-activity relationships indicated that both an ethyl group on the 4-position of the pyrimidine ring and alkyl chain as a para-substituent group of the benzene ring showed good biological activity.

Pyrazinamide compounds, preparation method and application thereof as well as bactericide

The invention relates to the field of pesticide bactericides and discloses pyrazinamide compounds, a preparation method and an application thereof as well as a bactericide. The compounds have the structure shown in formula (I). The pyrazinamide compounds with the novel structure are designed by introducing pyrazine ring fragments in Pyradiflumid and diphenyl ether fragments with wide bioactivity,and the pyrazinamide compounds can be used as novel SDHIs (succinate dehydrogenase inhibitors) or bactericides.

Pyrazinamide compounds and preparing method and application thereof and bactericide

The invention relates to the field of pesticide bactericides, and discloses a pyrazinamide compound and a preparing method and application thereof and a bactericide. The pyrazinamide compound has thestructure shown in the formula (I) or the formula (II) or the formula (III). According to the pyrazinamide compound and the preparing method and application thereof and the bactericide, by introducingpyrazine ring fragments and and diphenyl ether fragments with the wide biological activity in NNF-0721, and the pyrazinamide compound with the brand-new structure is designed; the pyrazinamide compound can serve as a brand-new succinodehydrogenase inhibitor or a bactericide. The formula is defined in the description.

Synthesis and Insecticidal Activity of Novel Thiazole Acrylonitrile Derivatives

A series of novel thiazole acrylonitrile derivatives was designed and synthesized utilizing NC-510 as a precursor. Their structures were characterized by NMR spectrometry, MS, and elemental analysis. The results of bioassay indicated that some of these ti