724437-21-2Relevant academic research and scientific papers
Studies on the acetylation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine-5- carbonitrile derivatives
Chioua, Mourad,Soriano, Elena,Samadi, Abdelouahid,Marco-Contelles
experimental part, p. 861 - 872 (2010/08/22)
(Chemical Equation Presented) The acetylation reaction of the differently substituted 3,6-diamino-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile derivatives 1-6 is reported. The structure of the resulting acetamides has been investigated and confirmed by analy
Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors
Chioua, Mourad,Samadi, Abdelouahid,Soriano, Elena,Lozach, Olivier,Meijer, Laurent,Marco-Contelles, Jose
supporting information; experimental part, p. 4566 - 4569 (2010/04/24)
The synthesis and biological evaluation of a number of differently substituted 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives are reported. From the inhibition results on a selection of disease-relevant protein kinases [IC50 (μM) DYRK1A = 11; CDK5 = 0.41; GSK-3 = 1.5] we have observed that 3,6-diamino-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (4) constitutes a potential new and simple lead compound in the search of drugs for the treatment of Alzheimer's disease.
