724445-31-2Relevant articles and documents
The synthesis of tetrahydropyridopyrimidones as a new scaffold for HIV-1 integrase inhibitors
Kinzel, Olaf D.,Monteagudo, Edith,Muraglia, Ester,Orvieto, Federica,Pescatore, Giovanna,Ferreira, Maria del Rosario Rico,Rowley, Michael,Summa, Vincenzo
, p. 6552 - 6555 (2008/02/12)
An efficient synthesis of methyl 9-amino-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate as a late stage intermediate for a new class of HIV-1 integrase inhibitors is described. After construction of the bicyclic core scaffold,