724454-79-9

Basic information

• Product Name: 1,3-benzothiazol-2-yl(2-methylphenyl)methanone
• Synonyms: 1,3-benzothiazol-2-yl(2-methylphenyl)methanone
• CAS NO: 724454-79-9
• Molecular Weight: 253.324
• Mol File: 724454-79-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1,3-benzothiazol-2-yl(2-methylphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-benzothiazol-2-yl(2-methylphenyl)methanone(724454-79-9)
• EPA Substance Registry System: 1,3-benzothiazol-2-yl(2-methylphenyl)methanone(724454-79-9)

Safety Data

• Hazardous Substances Data: 724454-79-9(Hazardous Substances Data)

Upstream product

• 95-16-9 1,3-Benzothiazole 
• 933-88-0 ortho-toluoyl chloride 
• 137-07-5 2-amino-benzenethiol 
• 22364-68-7 2-tolylmethylnitrile 
• 95-47-6 o-xylene 
• 118-90-1 ortho-methylbenzoic acid 
• 3991-75-1 N-(2-methylbenzoyl)imidazole 
• 577-16-2 2-Methylacetophenone 
• 32137-73-8 2-(trimethylsilyl)benzothiazole 

Downstream Products

• 1256158-36-7 bis(1,3-benzothiazol-2-yl)(2-methylphenyl)methanol 

Relevant articles and documents

Photoinduced remote heteroaryl migration accompanied by cyanoalkylacylation in continuous flow

A photoinduced 1,4-heteroaryl migration from a carbon center to a nitrogen center accompanied by a cyanoalkylacylation of heterocyclic-substituted azidyl homoallylic alcohols and cycloketone oxime esters has been described. This simple and powerful protoc

C2 substituted 2H-benzothiazole aryl acylated derivative, and synthesis method and application thereof

The invention discloses a C2 substituted 2H-benzothiazole aryl acylated derivative, and a synthesis method and application thereof. The preparation method of the derivative comprises the following steps: mixing substituted 2H-benzothiazole and substituted methyl benzene, adding into a solvent, in the presence of an oxidizing agent Selectfluor and an additive trifluoroacetic acid, carrying out a heating and stirring reaction in the air atmosphere, performing TLC monitoring is conducted till the reaction is finished, and separating and purifying the obtained reaction liquid to obtain the target product C2 substituted 2H-benzothiazole aryl acylated derivative. The substituted methyl benzene used in the invention is low in price, easy to obtain and good in chemical stability, the method has the advantages of being high in atom economy, simple in catalytic system, free of transition metal catalysts, good in product yield, wide in substrate range and the like, and the prepared compound structure can be further optimized as an anti-tumor drug lead.

Iodine- And TBHP-Promoted Acylation of Benzothiazoles under Metal-Free Conditions

A simple protocol for the synthesis of 2-acylbenzothiazoles using aryl ketones and benzothiazoles in the presence of I 2and TBHP is described. Acylation of the benzothiazoles is achieved through a sequence involving oxidation of the aryl ketone to an aryl glyoxal, ring-opening of the benzothiazole followed by condensation of the amino group with the aryl glyoxal, cyclization and oxidation. The method avoids the use of metals and toxic solvents. In addition, this protocol has the advantage of broad scope and provides good to excellent product yields.