72459-45-1

Usage

Uses

Used in Chemical Synthesis:
1-(2-Bromobenzyl)-1H-imidazole is used as a chemical intermediate for the synthesis of various organic compounds. Its unique molecular structure and reactivity make it a valuable component in the preparation of complex molecules.
Used in Pharmaceutical Applications:
1-(2-Bromobenzyl)-1H-imidazole is used as a building block in the development of pharmaceutical drugs. Its molecular structure and chemical behavior contribute to its potential as a therapeutic agent, with properties such as biological activity and potential interactions with biological targets being studied for medicinal purposes.
Used in Computational and Experimental Studies:
1-(2-Bromobenzyl)-1H-imidazole is used as a subject of study in computational and experimental research. Its properties, such as reactivity, spectrum, biological activity, and toxicity, are analyzed to understand its behavior and potential applications in various fields. This research can provide insights into its potential uses and limitations in chemical synthesis and pharmaceutical development.

Upstream product

• 14221-01-3 tetrakis(triphenylphosphine) palladium⁽⁰⁾ 
• 150691-04-6 2-(tert-butylamino)sulfonylphenylboronic acid 
• 288-32-4 1H-imidazole 
• 95-46-5 2-methylphenyl bromide 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Downstream Products

• 109483-87-6 2-Bromophenyl-1-(1-hydroxycycloheptyl)-1-imidazolylmethane 
• 4238-71-5 1-benzylimidazole 

Relevant academic research and scientific papers

Palladium-catalyzed intramolecular CH arylation of five-membered N-heterocycles

Intramolecular CH arylation of imidazole derivatives is carried out in the presence of a palladium catalyst to form fused heteroaromatic compounds. The reaction of imidazole with 2-iodobenzyl bromide with NaH gives the cyclization precursor in an excellen

Fused imidazole derivative having IDO/TDO inhibition activity and having structure represented by formula (I), preparation method and applications thereof

The present invention relates to a fused imidazole derivative having IDO/TDO inhibition activity and having a structure represented by a formula (I), a preparation method and applications thereof. According to the present invention, the series of the fused imidazole derivatives have high IDO/TDO inhibition activity, can be widely used for treating or preventing cancers or tumors, viral infections, depression, neurodegenerative disorders, trauma, age-related cataract, organ transplant rejections or autoimmune diseases, can further be used to inhibit the immune suppression of patients, and are expected to be developed into the new generation of the immunosuppressive agent. The formula (I) is defined in the specification.

TDO2 INHIBITORS

Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

Dual Catalysis in Domino N-Benzylation/Intramolecular C-H Arylation: Regio- and Chemoselective Synthesis of Annelated Nitrogen Heterocycles

A general method has been developed for the synthesis of fused nitrogen heterocycles by using a domino N-benzylation/C-H arylation reaction sequence. The details and yields of the domino process were compared with those of the two-step literature protocol

Angiotensin-II receptor blocking, heterocycle substituted imidazoles

Novel heterocycle substituted imidazoles of Formula (I), which are useful as angiotensin-II antagonists, are disclosed: STR1