724705-98-0Relevant academic research and scientific papers
Lactams as prostanoid receptor ligands. Part 4: 2-Piperidones as selective EP4 receptor agonists
Elworthy, Todd R.,Brill, Emma R.,Caires, Christopher C.,Kim, Woongki,Lach, Leang K.,Tracy, Jahari Laurant,Chiou, San-San
, p. 2523 - 2526 (2005)
2-Piperidones were prepared bearing heptanoic acid or a thioether heptanoic acid at the 1-position as well as appropriately substituted at the 6-position to mimic the structure of prostaglandins. The stereochemical purity at the 6-position was determined to be ≥95% ee for an advanced synthetic intermediate. The 2-piperidones were identified as potent agonists at the EP4 prostanoid receptor. They displayed a high affinity (K i 5-130 nM) at EP4 and subtype selectivity.
