724709-49-3

Upstream product

• 724709-46-0 3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-5'-O-tritylthymidine 
• 724709-45-9 3-N-(benzyloxymethyl)-3'-C-(hydroxymethyl)-5'-O-tritylthymidine 
• 583843-99-6 3'-C-(hydroxymethyl)-5'-O-tritylthymidine 
• 583843-93-0 (2S,3R,5R)-3-Benzyloxy-5-(3-benzyloxymethyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-methoxymethoxymethyl-tetrahydro-furan-2-carbaldehyde 
• 3587-60-8 Benzyloxymethyl chloride 
• 583843-94-1 3'-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine 
• 131607-35-7 3'-deoxy-3'-C-methylidene-5'-O-(triphenylmethyl)thymidine 

Relevant academic research and scientific papers

Synthesis and conformation of a novel bridged nucleic acid having a trans-fused 3,5,8-trioxabicyclo[5.3.0]decane structure

A novel bridged nucleic acid analogue, 2′-deoxy-trans-3′, 4′-BNA thymine monomer, was successfully synthesized. An ab initio calculation and X-ray structure analysis revealed that the trans-fused bicyclo[5.3.0]decane structure of the 2′-deoxy-trans-3′,4′-BNA effectively constrained the sugar puckering in C2′-endo with appropriate γ, δ and χ angles.