724746-23-0

Upstream product

• 851437-36-0 (4-(allyloxy)-3-bromophenyl)methanol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 106-95-6 allyl bromide 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 851437-35-9 4-(allyloxy)-3-bromobenzonitrile 

Downstream Products

• 851437-36-0 (4-(allyloxy)-3-bromophenyl)methanol 

Relevant academic research and scientific papers

Introducing the Tishchenko reaction into sustainable polymer chemistry

Taking advantage of the structural characteristics of lignin-derived phenolic compounds, a combination of the Williamson and Tishchenko reactions produced a series of new α,ω-diene functionalized carboxylic ester monomers from both petrochemical and renewable resources, which were applicable in subsequent thiol-ene click and acyclic diene metathesis (ADMET) polymerizations, providing a series of poly(thioether esters) and unsaturated aromatic-aliphatic polyesters with high molecular weights.

Diester monomer containing carboxylic ester structure, polyester thereof and sulfur-containing polyester (by machine translation)

The invention discloses a diester monomer containing a carboxylic ester structure, a polyester thereof and a sulfur-containing polyester. The monomer is prepared from vanillin, butyraldehyde, p-hydroxybenzaldehyde, 3 - fluorine -4 - hydroxybenzaldehyde, 3 - bromo -4 - hydroxybenzaldehyde and 3 - methyl -4 - hydroxybenzaldehyde, and the reaction product is recrystallized or separated to obtain an enal monomer; 2) is reacted, with an enal monomer as a raw material, without a solvent or dissolved in an organic solvent. After the reaction product is recrystallized or separated from the chromatographic column, a dicarboxylic monomer containing a carboxylic acid ester structure is obtained. The polyester is prepared under the action of Hoveveveda-Grubrubbs catalyst and p-benzoquinone. The sulfur-containing polyester is prepared by reacting with a dithiol compound. The novel monomer and the polymer, provided by the invention, have the advantages of abundant raw material sources, simple preparation process, no generation of inflammable and explosive low boiling volatile matters, environmental protection, universality and the like. (by machine translation)

Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria

There exists an urgent medical need to identify new chemical entities (NCEs) targeting multidrug resistant (MDR) bacterial infections, particularly those caused by Gram-negative pathogens. 4-Hydroxy-2-pyridones represent a novel class of nonfluoroquinolone inhibitors of bacterial type II topoisomerases active against MDR Gram-negative bacteria. Herein, we report on the discovery and structure-activity relationships of a series of fused indolyl-containing 4-hydroxy-2-pyridones with improved in vitro antibacterial activity against fluoroquinolone resistant strains. Compounds 6o and 6v are representative of this class, targeting both bacterial DNA gyrase and topoisomerase IV (Topo IV). In an abbreviated susceptibility screen, compounds 6o and 6v showed improved MIC90 values against Escherichia coli (0.5-1 μg/mL) and Acinetobacter baumannii (8-16 μg/mL) compared to the precursor compounds. In a murine septicemia model, both compounds showed complete protection in mice infected with a lethal dose of E. coli.

SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS

The present description relates to substituted polycyclic compounds of Formula (I), Formula (II) or Formula (III): wherein the dashed line represents an optional double bond and Rl, R2, R4, R5, R7, X and Z are as defined herein, and forms and compositions thereof, and also relates to uses of a compound of Formula (I), Formula (II) or Formula (III) or a form thereof and methods for treating or ameliorating Neisseria gonorrhoeae (N. gonorrhoeae) in a subject in need thereof comprising, administering an effective amount of the compound to the subject.

Selective oxidations of activated alcohols in water at room temperature

Allylic and benzylic alcohols can be selectively oxidized to their corresponding aldehydes or ketones in water containing nanoreactors composed of the designer surfactant TPGS-750-M. The oxidation relies on catalytic amounts of CuBr, bpy, and TEMPO, with N-methyl-imidazole; air is the stoichiometric oxidant. the Partner Organisations 2014.

ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE

The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens. The present description further relates to a compound having activity toward wild-type and MDR bacteria. The present description also relates to a compound having activity against quinolone-resistant Gram-negative strains (including MDR strains) as well as antibacterial activity to MDR resistant Gram-positive pathogens (including MRSA strains).

ALYKYLENE DERIVATIVE HAVING EDG RECEPTOR ANTAGONISM

PROBLEM TO BE SOLVED: To provide novel compounds having EDG (endothelial differentiation gene) receptor antagonism which are useful as active components of drugs for preventing and/or treating inflammatory diseases or the like. SOLUTION: The compounds are represented by formula (I) (wherein R1 is hydrogen or an alkyl group; R2 is hydrogen present at any substitutable position on ring C or a substituent such as a hydroxy group, a carboxy group, and a nitro group; R3 is hydrogen present at any substitutable position on ring D or a substitutent such as a hydroxy group and an aralkyloxy group; X is an alkylamino group, an amino group or the like; Y is a carboxy group, a sulfo group or a phosphono group; Z is oxygen, sulfur or the like; a ring represented by A is a 5- or 6-membered saturated or unsaturated hydrocarbon ring; and a ring represented by B is a 4- or 7-membered saturated or unsaturated hydrocarbon ring containing one -C=C- as a partial structure shown in the above formula) and include their salts and their esters.