724770-74-5 Usage
Uses
Used in Organic Synthesis:
6-Bromo-2-ethylaminopyridine, HCl is used as a reagent in organic synthesis for the preparation of various pharmaceuticals and fine chemicals. Its unique structural features, including the bromine atom and ethylamine group, make it a valuable component in the creation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-Bromo-2-ethylaminopyridine, HCl is utilized as a key intermediate in the synthesis of biologically active molecules. Its presence in the molecular structure can influence the pharmacological properties of the final product, contributing to the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
6-Bromo-2-ethylaminopyridine, HCl is also employed in chemical research as a model compound to study the effects of bromine substitution on the reactivity and properties of pyridine derivatives. This research can lead to a better understanding of the underlying chemical mechanisms and the development of novel synthetic strategies.
Overall, 6-Bromo-2-ethylaminopyridine, HCl is a versatile chemical compound with applications spanning across organic synthesis, pharmaceutical development, and chemical research, highlighting its importance in the field of chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 724770-74-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,2,4,7,7 and 0 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 724770-74:
(8*7)+(7*2)+(6*4)+(5*7)+(4*7)+(3*0)+(2*7)+(1*4)=175
175 % 10 = 5
So 724770-74-5 is a valid CAS Registry Number.
724770-74-5Relevant academic research and scientific papers
German, Nadezhda,Decker, Ann M.,Gilmour, Brian P.,Gay, Elaine A.,Wiley, Jenny L.,Thomas, Brian F.,Zhang, Yanan
, p. 7758 - 7769 (2014)
The recent discovery of allosteric modulators of the CB1 receptor including PSNCBAM-1 (4) has generated significant interest in CB1 receptor allosteric modulation. Here in the first SAR study on 4, we have designed and synthesized a series of analogs focusing on modifications at two positions. Pharmacological evaluation in calcium mobilization and binding assays revealed the importance of alkyl substitution at the 2-aminopyridine moiety and electron deficient aromatic groups at the 4-chlorophenyl position for activity at the CB1 receptor, resulting in several analogs with comparable potency to 4. These compounds increased the specific binding of [3H]CP55,940, in agreement with previous reports. Importantly, 4 and two analogs dose-dependently reduced the Emaxof the agonist curve in the CB1 calcium mobilization assays, confirming their negative allosteric modulator characteristics. Given the side effects associated with CB1 receptor orthosteric antagonists, negative allosteric modulators provide an alternative approach to modulate the pharmacologically important CB1 receptor.
