72479-26-6 Usage
Originator
Lomexin,Effik
Uses
Different sources of media describe the Uses of 72479-26-6 differently. You can refer to the following data:
1. Antifungal.
2. Isotope labelled Fenticonazole Nitrate broad spectrum antimycotic; also active as antibacterial. Antifungal (topical).
Manufacturing Process
1-(2',4'-Dichlorophenyl)-2-chloroethanol:49.5 g of sodium borohydride were added slowly and in small parts to a
suspension of 233 g of 1-(1'-hydroxy-2'-chloroethyl)-2,4-dichlorobenzene in 1
liter of methanol stirred at room temperature. The solution thus obtained was
stirred at room temperature for a further two hours, and it was then poured
into 1 liter of 5 N hydrochloric acid cooled with ice. After extraction with ethyl
acetate or chloroform, the extract was washed with water, with 1 N sodium
hydroxide, then again with water until neutrality, and finally with a saturated
sodium chloride solution. The extract was dried, the solvent evaporated off
and 220 g of an oil were obtained. The oil solidified on standing and the solid
1-(2',4'-dichlorophenyl)-2-chloro-ethanol melted at 48-51°C.1-(2',4'-Dichlorophenyl)-2-(N-imidazolyl)ethanol:30 g of sodium were added to a solution of 88.5 g of imidazole in 600 ml of
methanol; the solvent was then evaporated off. The residue was dissolved in
300 ml of dimethylformamide and heated to 115-120°C. To the solution so
obtained was added, dropwise and under stirring, a solution of 225 g of 1-
(2',4'-dichlorophenyl)-2-chloroethanol in 400 ml of dimethylformamide. The
mixture was heated to 115-120°C and maintained at that temperature for 20
min and, after subsequent cooling to 40°C, 2500 ml of iced water were added
under vigorous stirring. The product precipitated under stirring over a period
of about two hours, the upper liquid was then decanted off, a further 2500 ml
of water were added and, after standing, the whole was filtered. The
precipitate thus obtained was dried and crystallized from toluene. 170 g of the
1-(2',4'-dichlorophenyl)-2-(N-imidazolyl)ethanol, melting at 134-135°C, was
obtained.METHOD 1:A solution of 2.57 g of 1-(2',4'-dichlorophenyl)-2-(N-imidazolyl)ethanol in 10
ml of hexamethylphosphoramide was dropped at 25°C into a suspension of
0.52 g of sodium hydride (50% in oil) in 5 ml of hexamethylphosphoramide.
When hydrogen emission was over, the salification was completed by heating
for 1 hour at 50°C. After cooling to 25°C, 2.58 g of 1-chloromethyl-4-
phenylthiobenzene were added. The temperature was raised to 50°C and
maintained at that temperature for 12 hours. At the end of the reaction, the
mixture was poured into 200 ml of water, the product was extracted with
diethyl ether, the solvent was evaporated off and the residue was purified
twice on a silica gel column, using ethyl acetate as eluant and testing the
various fractions by TLC. The solvent was evaporated off the middle fractions to give 2.4 g of the 1-[2,4-dichloro-beta-[[p-(phenylthio)benzyl]oxy]
phenethyl]imidazole as a yellowish oil, showing a single spot on TLC.METHOD 2:0.66 g of sodium hydride (50% in oil) were added at 20-30°C and under
nitrogen atmosphere to 3.86 g of 1-(2',4'-dichlorophenyl)-2-(N-imidazolyl)
ethanol in 15 ml of dimethylsulphoxide (dried on calcium hydride). The
mixture was heated under stirring at 50-60°C until gas emission was over.
After cooling to 20-25°C, 0.5 g of potassium iodide were added and slowly a
solution of 3.51 g of 1-chloromethyl-4-phenylthiobenzene in 4 ml of
dimethylsulphoxide was dropped in. The mixture was stirred at 20-25°C until
addition of the 1-chloromethyl-4-phenylthiobenzene was over. The mixture
was then poured into 150 ml of water and extracted with diethyl ether. To the
etheric solution, after drying on anhydrous sodium sulphate, was added
excess 4 N nitric acid solution in diethyl ether: the desired product
precipitated as nitrate, an oil which solidified on standing. After standing for
20 hours, the etheric liquid was decanted off and the residue was crystallized
from ethanol. The nitrate thus obtained, not completely pure, was dissolved in
water and excess sodium carbonate was added in order to liberate the base
which was then extracted with ethyl acetate. The base, obtained by filtration,
was purified on a silica gel column using ethyl acetate as eluant. The
combined fractions containing the desired product were evaporated to
dryness. The residue was dissolved in diethyl ether, again transformed into
the nitrate and crystallized from ethanol. Yield: 3.1 g of a white crystalline
powder, melting at 136°C; λmax 252 nm (methanol).
Therapeutic Function
Antifungal
Check Digit Verification of cas no
The CAS Registry Mumber 72479-26-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,4,7 and 9 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 72479-26:
(7*7)+(6*2)+(5*4)+(4*7)+(3*9)+(2*2)+(1*6)=146
146 % 10 = 6
So 72479-26-6 is a valid CAS Registry Number.
InChI:InChI=1/C24H20Cl2N2OS/c25-19-8-11-22(23(26)14-19)24(15-28-13-12-27-17-28)29-16-18-6-9-21(10-7-18)30-20-4-2-1-3-5-20/h1-14,17,24H,15-16H2
72479-26-6Relevant articles and documents
New α-aryl-β,N-imidazolylethyl benzyl and naphthylmethyl ethers with antimycotic and antibacterial activity
Nardi,Cappelletti,Catto,Leonardi,Tajana,Veronese
, p. 2123 - 2126 (2007/10/02)
A new series of α-aryl-β,N-imidazolylethyl benzyl and naphthylmethyl ethers was synthesized and tested for antimycotic and antimicrobial activity. All compounds showed antifungal activity; most of them were also active against gram-positive bacteria, whereas no activity was detected against gram-negative bacteria. Structure-activity relationships are discussed. The α-(2,4-dichlorophenyl)-β,N-imidazolylethyl 4-phenylthiobenzyl ether nitrate (8), which showed good ski tolerability and in vivo antimycotic activity comparable with or better than 1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazole (miconazole) and 1-[α-(o-chlorophenyl)benzhydryl]imidazole (clotrimazole), was selected for further researches.
