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Bausteine von Oligosacchariden, XX. Synthese der Oligosaccharid-Determinanten der Blutgruppensubstanzen der Type 2 des ABH-Systems. Diskussion der &α-Glycosid-Synthese
Paulsen, Hans,Kolar, Cenek
, p. 306 - 321 (2007/10/02)
The antigenic determinants of type 2 of blood-group substances A and B (23 and 24) as well as blood-group substance H (17) were synthesized by selective glycosidation reactions combined with a series of blocking and deblocking steps.The possibilities and optimization of the α-glycoside synthesis are discussed.In hemagglutination inhibition tests the synthetic haptens A and B of type 2 and type 1 show a similar selective inhibitory effect.In case of hapten H, however, great differences can be observed.Here the type 2 exhibited a strong inhibition activity, whereas type 1 only showed an extremly low activity.This leads to the conclusion that in the determinants of the ABH-system on the surface of erythrocytes the chemical structure of type 2 is predominating.
