72492-12-7

Usage

Uses

Used in Pharmaceutical Industry:
Spizofurone is used as an antiulcer agent for its ability to increase mucus secretion and microcirculation in the gastric mucosa, as well as its inhibitory effect on acid secretion. This makes it a beneficial treatment option for individuals suffering from ulcers and other gastrointestinal conditions.
Used in Gastrointestinal Health:
Spizofurone is used to support gastrointestinal health by promoting the protective functions of the stomach lining through increased mucus secretion and improved microcirculation. Its ability to inhibit acid secretion also contributes to its effectiveness in managing and preventing ulcers and other gastric issues.

Originator

Takeda (Japan)

InChI:InChI=1/C12H10O3/c1-7(13)8-2-3-10-9(6-8)11(14)12(15-10)4-5-12/h2-3,6H,4-5H2,1H3

Upstream product

• 72491-93-1 C₁₃H₁₀O₅ 
• 80901-29-7 methyl 5-acetyl-2-<(tetrahydro-2-oxo-3-furanyl)oxyl>benzoate 
• 72492-92-3 5-Acetyl-2-(2-oxo-tetrahydro-furan-3-yloxy)-benzoic acid 
• 16475-90-4 estere metilico dell'acido 5-acetilsalicilico 
• 5061-21-2 α-bromo-γ-butyrolactone 

Downstream Products

• 95449-95-9 Toluene-4-sulfonic acid 2-(5-acetyl-benzofuran-2-yl)-ethyl ester 

Relevant academic research and scientific papers

Spirocyclopropane compounds. III. Synthesis of spiro[benzofuran-2(3H),1'-cyclopropan]-3-ones for evaluation of gastric antisecretory and antiulcer agents

Spiro[benzofuran-2(3H),1'-cyclopropan]-3-one (VI-1) and its derivatives (VI-2 - VI-75) were synthesized in the same manner as described previously for the synthesis of spiro[cyclopropane-1,2'-[2H]indol]-3'(1'H)-ones (I). These spiro[benzofuran-2(3H),1'-cy

Spirocyclopropane compounds. V. One-step synthesis of 5-acetyl-spiro[benzofuran-2(3H),1'-cyclopropan]-3-one

5-Acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one (3a, AG-629), previously found to be the most potent antiulcer compound in a series of spirocyclopropanes, was obtained by one step synthesis starting from methyl 5-acetyl-2-[(tetrahydro-2-oxo-3-furanyl)oxy]benzoate (1a). In this reaction, 5,10'-(diacetyl-5',6'-dihydrospiro[benzofuran-2(3H),4'(3'H)-[2H]oxocino[3, 2-b]-benzofuran]-3-one (5a), which has a new ring system, and 1H,3H-8-acetyl-4,5-dihydro-naphtho[1,2-c:4,3-b']difuran-1-one (6) were isolated as by-products. A possible reaction mechanism is presented.

Spirobenzofuranone compounds

Novel spirobenzofuranone compounds of the formula: STR1 have gastric secretion inhibitive, antiinflammatory and analgesic activities, and are of value as drugs.