7250-80-8

Basic information

• Product Name: N-hexylbenzenesulfonamide
• Synonyms: benzenesulfonamide, N-hexyl-
• CAS NO: 7250-80-8
• Molecular Formula: C₁₂H₁₉NO₂S
• Molecular Weight: 241.3498
• Mol File: 7250-80-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 355.6°C at 760 mmHg
• Flash Point: 168.9°C
• Density: 1.084g/cm³
• Vapor Pressure: 3.09E-05mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: N-hexylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-hexylbenzenesulfonamide(7250-80-8)
• EPA Substance Registry System: N-hexylbenzenesulfonamide(7250-80-8)

Safety Data

• Hazardous Substances Data: 7250-80-8(Hazardous Substances Data)

Upstream product

• 111-26-2 hexan-1-amine 
• 98-09-9 benzenesulfonyl chloride 
• 873-55-2 sodium benzenesulfonate 

Downstream Products

• 52374-05-7 C₁₈H₂₃NO₄S₂ 
• 1190977-78-6 C₁₄H₁₈Cl₃NO₃S 

Relevant articles and documents

Copper-Catalyzed Amide Radical-Directed Cyanation of Unactivated Csp3-H Bonds

A method for site-selective intermolecular δ/?-Csp3-H cyanation of aliphatic sulfonamides is developed using TsCN as the cyanating reagent, catalyzed by a Cu(I)/phenanthroline complex. The mild, expeditious, and modular protocol allows efficient remote Csp3-H cyanation with good functional group tolerance and high regioselectivity. Mechanistic studies indicate that the reaction might proceed through a Cu(I)-mediated N-F bond cleavage to generate an amidyl radical, 1,5-HAT, and cyano group transfer of the resulting carbon radical with TsCN.

A general and mild two-step procedure for the synthesis of aryl and heteroaryl sulfonamides from the corresponding iodides

A mild two-step preparation of aryl and heteroaryl sulfonyl chlorides and sulfonamides from their corresponding iodides is developed. Acid labile functionalities are shown to be stable under both the copper-catalysed coupling and the subsequent oxidative chlorination.

Chemistry of Organic Chloramines. Formation of Arenesulfonamides by Derivatization of Organic Chloramines with Sodium Arenesulfinates

Organic chloramines react rapidly with sodium benzenesulfinate or sodium toluenesulfinate to form arenesulfonamides.Derivatization was carried out by three different methods, one involving derivatization of pure chloramines and two involving derivatization of the chloramines generated in situ by reaction of the amine with sodium hypochlorite.Seventeen arenesulfonamides whose amine precursors included primary and secondary aliphatic amines, aromatic amines, and amino acids were synthesized in poor to excellent yields depending on the method used.Effects of structure,stability, and water solubility of the chloramine precursors are discussed.Benzenesulfonyl chloride can be isolated from the reaction of 10-4 M N-chloropiperidine with sodium benzenesulfinate.Competing hydrolysis of the sulfonyl chloride accounts for low yields of sulfonamide for dilute solutions of chloramine.