72517-19-2

Usage

Physical appearance

Yellow crystalline powder

Usage

Reagent in biochemical and organic synthesis

Chemical structure

Derivative of benzoic acid with two hydroxyl (-OH) groups and a nitro (-NO2) group attached to the benzene ring

Applications

Preparation of pharmaceuticals, chelating agent in metal ion detection assays

Known properties

Antioxidant, antimicrobial

Valued in fields

Medicine, food preservation, cosmetics

Upstream product

• 619-17-0 4-Nitroanthranilic acid 
• 61203-50-7 3-methoxy-2-hydroxy-4-nitrobenzoic acid 
• 7150-01-8 2-acetoxy-3-methoxybenzaldehyde 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 20041-61-6 2-hydroxy-3-methoxy-4-nitrobenzaldehyde 

Downstream Products

• 61203-56-3 methyl 2,3-dimethoxy-4-nitrobenzoate 
• 183005-93-8 2,3-Dihydroxy-4-nitro-benzoic acid methyl ester 
• 183005-94-9 4-Ethoxycarbonylamino-2,3-dihydroxy-benzoic acid methyl ester 
• 183005-98-3 4-Amino-2,3-bis-ethoxycarbonyloxy-benzoic acid methyl ester 
• 183005-96-1 4-Ethoxycarbonylamino-2-ethoxycarbonyloxy-3-hydroxy-benzoic acid methyl ester 
• 1312609-92-9 C₁₈H₁₄Br₂O₄ 
• 1312609-95-2 C₃₈H₄₆N₂O₁₂ 
• 1312609-96-3 C₃₈H₄₆N₆O₆ 
• 1312608-48-2 C₄₂H₅₂N₈O₈ 
• 1312610-07-3 C₁₀H₉BrO₄ 
• 1312610-08-4 C₁₈H₁₆O₆ 
• 1312610-09-5 C₁₅H₁₀O₆ 
• 1312610-10-8 C₁₅H₈Cl₂O₄ 
• 1312610-11-9 C₁₇H₁₂Br₂O₄ 

Relevant academic research and scientific papers

NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Synthesis of 4-chloro-7-ethoxy-2(3H)-benzoxazolone-6-carboxylic acid

As a part of metabolic studies of mosapride (1), a potential gastroprokinetic agent, the synthesis of 4-chloro-7-ethoxy-2(3H)-benzoxazolone-6-carboxylic acid (7) as a derivative of 4-amino-5-chloro-2-ethoxy-3-hydroxybenzoic acid (6), which has served a benzoic acid part of the metabolites 4 and 5, is described. Treatment of methyl 3-amino-4-substituted amino-5-chloro-2-ethoxybenzoate derivatives 11a-c with sodium nitrate in acidic medium gave the benzotriazole derivatives 13x,y instead of the objective 3-hydroxy counterpart. The synthesis of 7 started from o-vanillin acetate (15) and proceeded through the intermediates 2-hydroxy-3-methoxy-4-nitrobenzaldehyde (18), methyl 4-amino-2,3-dihydroxybenzoate (23), and methyl 7-hydroxy-2(3H)-benzoxazolone-6-carboxylate (30). Compound 30 was alternatively prepared from 23 via methyl 4-ethoxycarbonylamino-2-ethoxycarbonyloxy-3-hydroxybenzoate (29), which is the product resulting from the migration of the ethoxycarbonyl group of methyl 4-amino-2,3-diethoxycarbonyloxybenzoate (27).