7252-84-8

Basic information

• Product Name: 3-AMINO-6-METHOXYPYRIDAZINE
• Synonyms: 3-AMINO-6-METHOXYPYRIDAZINE;6-methoxypyridazin-3-amine;3-AMINO-6-METHOXYPYRIDAZINE, 95+%;6-Methoxy-pyridazin-3-ylamine;6-Methoxy-3-pyridazinamine;3-Methoxy-6-aminopyridazine;6-Amino-3-methoxypyridazine;NSC 73703
• CAS NO: 7252-84-8
• Molecular Formula: C₅H₇N₃O
• Molecular Weight: 125.13
• EINECS: 230-670-1
• Product Categories: Pyridines
• Mol File: 7252-84-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 108-109℃
• Boiling Point: 353.5 °C at 760 mmHg
• Flash Point: 167.6 °C
• Appearance: /
• Density: 1.224
• Vapor Pressure: 3.57E-05mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C(protect from light)
• PKA: 5.84±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-6-METHOXYPYRIDAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-6-METHOXYPYRIDAZINE(7252-84-8)
• EPA Substance Registry System: 3-AMINO-6-METHOXYPYRIDAZINE(7252-84-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 7252-84-8(Hazardous Substances Data)

Usage

General Description

3-Amino-6-methoxypyridazine is a chemical compound with the molecular formula C5H7N3O and a molecular weight of 125.13 g/mol. It is a pyridazine derivative containing an amino group and a methoxy group at the 3 and 6 positions, respectively. 3-Amino-6-methoxypyridazine is a potential building block in organic synthesis and pharmaceutical research due to its unique chemical structure and reactivity. It is commonly used as a precursor in the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, 3-Amino-6-methoxypyridazine has shown potential pharmacological and biological activities, making it an interesting compound for further study and application in the fields of medicine and drug discovery.

InChI:InChI=1/C5H7N3O/c1-9-5-3-2-4(6)7-8-5/h2-3H,1H3,(H2,6,7)

Upstream product

• 80-35-3 Sulfamethoxypyridazine 
• 1722-10-7 3-chloro-6-methoxypyridazine 
• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 124-41-4 sodium methylate 

Downstream Products

• 64068-06-0 6-methoxy-imidazo[1,2-b]pyridazine-2-carboxylic acid ethyl ester 
• 64068-09-3 6-methoxyimidazo[1,2-b]pyridazine-2-carboxylic acid 
• 80-35-3 Sulfamethoxypyridazine 
• 1586822-67-4 3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(6-methoxypyridazin-3-yl)benzamide 

Relevant articles and documents

Photodegradation of sulfamethazine, sulfamethoxypiridazine, amitriptyline, and clomipramine drugs in aqueous media

The photochemical transformation of two antibacterial sulfonamides, namely sulfamethazine (SMT) and sulfamethoxypyridazine (SMP), and two tricyclic antidepressants, namely amitriptyline (AMT) and clomipramine (CMP) were investigated. Experiments conducted in river water under artificial sunlight irradiation show an acceleration of the degradation for SMT, SMP, and CMP of a factor 1.6–7.7 by comparison to purified water. This acceleration is, at least partially, due to photosensitized reactions which can occur in river water. The photodegradation of CMP was particularly fast. In addition, no degradation was observed for AMT in purified water while photosensitized reaction occurs. Under ultra-violet (254?nm) irradiation in purified water, the four drugs were degraded. Calculated quantum yields of photodegradation were of 4.3?×?10?3, 5.1?×?10?3, 7.6?×?10?3, and 65.0?×?10?3 respectively for SMT, SMP, AMT, and CMP. UV coupled with hydrogen peroxide (UV/H2O2) was used as an advanced oxidation process for water depollution. The calculated second order rate constants of reaction with hydroxyl radicals were of 5.0?×?109, 5.0?×?109, 8.0?×?109 and 9.5?×?109?L?mol?1?s?1 for SMT, SMP, AMT and CMP, respectively. Finally, the structures of photoproducts were proposed according to LC–MS/MS analyses. The elimination of SO2 was the main photochemical process for SMT and SMP. In the case of AMT and CMP, hydration and hydroxylation, respectively, were observed.

Selective Cross-Coupling of (Hetero)aryl Halides with Ammonia to Produce Primary Arylamines using Pd-NHC Complexes

Herein we report the first example of (hetero)arylation of ammonia using a monoligated palladium-NHC complex. The new, rationally designed, precatalyst (DiMeIHeptCl)Pd(allyl)Cl featuring highly branched alkyl chains has been shown to be effective in selective aminations across a range of challenging substrates, including nitrogen-containing heterocycles and those featuring base-sensitive functionality. The less bulky Pd-PEPPSI-IPentCl precatalyst performs well for ortho-substituted aryl halides, giving monoarylated products in high yield with good selectivity.

THERAPEUTICALLY ACTIVE THIAZOLO-PYRIMIDINE DERIVATIVES

A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.