7252-87-1

Upstream product

• 143-15-7 1-dodecylbromide 
• 105-53-3 diethyl malonate 
• 996-82-7 sodium diethylmalonate 

Downstream Products

• 103164-01-8 4-dodecyl-1,2-diphenyl-pyrazolidine-3,5-dione 
• 71366-37-5 2-dodecylpropane-1,3-diyl bistoluene p-sulfonate 
• 105040-45-7 5-dodecyl-3,7-dioxanonane-1,9-diol ditosylate 
• 22089-80-1 tetracosane-10,11-dione 
• 136434-87-2 bis<4-(5-dodecyl-1,3-dioxan-2-yl)phenyl>terephthalate 
• 890661-17-3 2-cyclohexyl-5-dodecyl-2-phenyl-1,3-dithiane 
• 4371-74-8 dodecylmalonic acid 

Relevant academic research and scientific papers

Annelides. 3. Complexation of Dioxygen in Organized Cobaltous Complex Assemblies. A New Approach to Kinetic Studies in Micellar Phases

Amphiphilic ligands belonging to the Annelide class are synthesized and shown to form complexes with transition-metal cation.By aggregation, these complexes can be organized into supermolecular structures.For the first time, it is shown that the formation of micellar phases of cobaltous complexes can lead to a dramatic enhancement of the dioxygen stability constant.Kinetic measurements have been performed to elucidate the mechanism of complexation and, in particular, the respective contributions of the local concentrations, the dimensionality of the reaction, and the orientation of the reactants upon the micellar effect.A new theoretical approach is presented to rationalize the chemical reactions in micellar phases by using the Prigogine-Flory model.

NOVEL MESITYLENE-CORED AMPHIPHILES AND USES THEREOF

The present invention relates to a mesitylene-cored amphiphile, a method of preparing the same and a method of extraction, solubilization, stabilization, crystallization or analysis of a membrane protein using the same. When a mesitylene-cored compound according to the present invention is used, membrane proteins can be stored in a stable conformation for a long time in an aqueous solution in comparison with conventional compounds, by which the membrane proteins are usable in both functional and structural analyses thereof. The functional and structural analyses of membrane proteins are one of the fields that are most spotlighted in current biology and chemistry. The present invention can be used to research on a protein structure closely related to new drug development.

NOVEL XYLENE-BASED AMPHIPHILIC COMPOUND AND USE THEREOF

The present invention relates to a xylene-based amphiphilic compound, a method for preparing the same, and a method for extracting, solubilizing, stabilizing or crystallizing a membrane protein using the same. By using the xylene-based compound according to the present invention, a membrane protein may be stably stored in an aqueous solution for a long time, and may be applied in functional and structural analyses. The structural and functional analysis of the membrane protein is one of the fields of highest interest in biology and chemistry, and the xylene-based compound according to the present invention can be applied in research on protein structure that is closely related to development of a new drug.

Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy

Detergents serve as useful tools for membrane protein structural and functional studies. Their amphipathic nature allows detergents to associate with the hydrophobic regions of membrane proteins whilst maintaining the proteins in aqueous solution. However

Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation

Membrane proteins are key functional players in biological systems. These biomacromolecules contain both hydrophilic and hydrophobic regions and thus amphipathic molecules are necessary to extract membrane proteins from their native lipid environments and

Synthetic blocking reagents

The present invention concerns novel synthetic blocking reagents for the reduction of non-specific bindings in solid phase assays that rely on biological and specific recognition, e.g., in enzyme-linked immunosorbent assays (ELISAs). The invention provides the use of compounds as blocking reagents as well as kits comprising these compounds. The compounds comprise one or more poly(ethylene glycol) moieties, one or more alkyl- or aminoalkyl groups and another unit bridging the aforementioned groups, wherein the compound comprises at least one amino group.

Preparation and application of odorless 1,3-propanedithiol reagents

2-Dodecyl-1,3-propanedithiol (2a) was prepared without a malodorous procedure as an odorless reagent that was usable in place of 1,3-propanedithiol (1) in organic reactions, e.g., in the reduction of azides and protection of carbonyl groups. The 1,3-dithioacetals obtained in the latter reaction were effectively reduced to methylene with Raney nickel and reconverted to the original carbonyl compounds by hydrolysis with N-bromosuccinimide in aqueous 2-butanone. In addition, the anion of 1,3-dithiane prepared from 2a and formaldehyde could be utilized as a synthetic equivalent of an anionic carbonyl carbon.

Synthesis of new lipophilic Ortho-dicarboranes

The synthesis of several new lipoidal dicarborane compounds prepared by reaction of decaborane with several fatty mona- and bis-alkyl-1,3-diols is described.

New types of nonionic surfactants with sugar head groups

The head group/lipophilic tail ratio is used to categorize amphiphilic compounds into different types. Some representatives of the 2/1 type with two sugar head groups and one lipophilic chain, namely compounds 6a-d, were synthesized from readily available precursors. Similarly, from 2,3-di-O-alkyl and 1,3-di-O-alkyl derivatives of D-threitol 2/2-type amphiphiles 13a-d, 15a-d and 20a-d, respectively, were obtained. Due to the different spatial demand of the sugar moieties relative to the lipophilic part, surface tension (σ) and critical micelle concentration (cmc) are clearly distinguished in these different structural types of nonionic surfactants. VCH Verlagsgesellschaft mbH, 1996.

Synthesis and Complex Chemistry of Functionalised Tripod Ligands RC(CH2PPh2)3

Malonic ester 1 is alkylated and converted into the triols RC(CH2OH)3 (5).These are easily converted into the corresponding functionalised tripodal ligands RC(CH2PPh2)3 (7) with R = Bzl (a), n-C12H25 (b), (CH3)2CH(CH2)2 (c).Crystals suitable for X-ray crystallography have been obtained of the ligand 7a.In addition, the tripod ligands 7a and 7c have been further characterized by the syntheses and X-ray analyses of the nickel complex (8a), the iron complex (BF4)2 ; and the cobalt complex >(BPh4)(10*BF4). - Key Words: Tripod ligand synthesis / Tripod nickel chloro complexes / Tripod iron tris(acetonitrile) complexes / Tripod cobalt acetate complexes