725239-76-9Relevant academic research and scientific papers
Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta
Hangeland, Jon J.,Doweyko, Arthur M.,Dejneka, Tamara,Friends, Todd J.,Devasthale, Pratik,Mellstroem, Karin,Sandberg, Johnny,Grynfarb, Marlena,Sack, John S.,Einspahr, Howard,Faernegardh, Mathias,Husman, Bolette,Ljunggren, Jan,Koehler, Konrad,Sheppard, Cheryl,Malm, Johan,Ryono, Denis E.
, p. 3549 - 3553 (2007/10/03)
A set of thyromimetics having improved selectivity for TR-β1 were prepared by replacing the 3′-isopropyl group of 2 and 3 with substituents having increased steric bulk. From this limited SAR study, the most potent and selective compounds ident
