409366-27-4

Basic information

• Product Name: METHYL(3,5-DICHLORO-4-HYDROXYPHENYL)ACETATE
• Synonyms: METHYL(3,5-DICHLORO-4-HYDROXYPHENYL)ACETATE;(3,5-dichloro-4-hydroxyphenyl)acetic acid Methyl ester;methyl 2-(3,5-dichloro-4-hydroxyphenyl)acetate
• CAS NO: 409366-27-4
• Molecular Formula: C₉H₈Cl₂O₃
• Molecular Weight: 235.06
• Mol File: 409366-27-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL(3,5-DICHLORO-4-HYDROXYPHENYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL(3,5-DICHLORO-4-HYDROXYPHENYL)ACETATE(409366-27-4)
• EPA Substance Registry System: METHYL(3,5-DICHLORO-4-HYDROXYPHENYL)ACETATE(409366-27-4)

Safety Data

• Hazardous Substances Data: 409366-27-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 788824-07-7 C₁₄H₁₆Cl₂O₅ 
• 156-38-7 4-hydroxyphenylacetate 
• 59595-92-5 chlorure de dichloro-3,5 hydroxy-4 benzoyle 
• 3336-41-2 3,5-dichloro-4-hydroxybenzoic acid 
• 89894-49-5 (3,5-dichloro-4-hydroxyphenyl)acetic acid 

Downstream Products

• 788824-08-8 [3,5-dichloro-4-(3-formyl-4-methoxy-phenoxy)-phenyl]-acetic acid methyl ester 
• 788824-22-6 [4-(3-bromo-4-methoxy-phenoxy)-3,5-dichloro-phenyl]-acetic acid methyl ester 
• 788824-09-9 5-(2,6-dichloro-4-methoxycarbonylmethyl-phenoxy)-2-hydroxy-benzoic acid 
• 788824-21-5 [3,5-dichloro-4-(6-methoxy-biphenyl-3-yloxy)-phenyl]-acetic acid methyl ester 

Relevant articles and documents

THYROID HORMONE RECEPTOR AGONISTS

Provided herein are novel thyroid hormone receptor (TR) agonists, e. g., having Formula I, II, or III. Also provided are methods of preparing the novel TR agonists and method of using the novel TR agonists for treating diseases or disorder modulated by TR agonists, such as NAFLD, NASH, diabetes, hyperlipidemia and/or hypercholesterolemia.

Synthesis of (+)-O-methylthalibrine by employing a stereocontrolled Bischler-Napieralski reaction and an electrochemically generated diaryl ether

An efficient electrochemical four-step route was developed for the preparation of diaryl ether derivatives by using halogenation and dehalogenation processes in addition to electrochemical phenolic oxidation and reduction reactions. The synthesis of (+)-O

Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin

As an extension of our analysis of the effect of halogenation on thiourea TRPV1 agonists, we have now modified selected 4-hydroxy(or 4-amino)-3- methoxyphenyl acetamide TRPV1 agonists by 5- or 6-halogenation on the aromatic A-region and evaluated them for potency for TRPV1 binding and regulation and for their pattern of agonism/antagonism (efficacy). Halogenation shifted the functional activity at TRPV1 toward antagonism with a greater extent of antagonism as the size of the halogen increased (I > Br > Cl), as previously observed for the thiourea series. The extent of antagonism was greater for halogenation at the 5-position than at the 6-position, in contrast to SAR for the thiourea series. In this series, compounds 55 and 75 showed the most potent antagonism, with Ki (ant) = 2.77 and 2.19 nM, respectively, on rTRPV1 expressed in Chinese hamster ovary cells. The compounds were thus ca. 40-60-fold more potent than 6′-iodononivamide.