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Usage

Uses

Used in Organic Synthesis:
(1E)-1-(biphenyl-4-ylmethylidene)-2-phenylhydrazine is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure and functional groups make it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Production:
As a hydrazine derivative, (1E)-1-(biphenyl-4-ylmethylidene)-2-phenylhydrazine may be used as an intermediate in the production of pharmaceuticals. Its specific structure could be leveraged to develop new drugs with novel therapeutic properties.
Used in Agricultural Chemicals:
(1E)-1-(biphenyl-4-ylmethylidene)-2-phenylhydrazine may also find applications in the development of agricultural chemicals, such as pesticides or herbicides. Its unique structure could potentially lead to the creation of new compounds with improved efficacy and selectivity.
Note: Further research and testing are required to fully understand the properties and potential uses of (1E)-1-(biphenyl-4-ylmethylidene)-2-phenylhydrazine in these industries.

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 3218-36-8 4-Phenylbenzaldehyde 
• 100-63-0 phenylhydrazine 
• 3597-91-9 biphenyl-4-yl methanol 

Downstream Products

• 50656-03-6 N-phenyl-1,1-biphenyl-4-ylcarbohydrazonoyl chloride 

Relevant academic research and scientific papers

Facile One-Pot Transformation of Primary Alcohols into 3-Aryl- and 3-Alkyl-isoxazoles and -pyrazoles

Various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylisoxazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, NH 2 OH, and then NCS, followed by reaction with alkynes in the presence of Et 3 N. Similarly, various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylpyrazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, PhNHNH 2, and then NCS and decyl methyl sulfide, followed by reaction with alkynes in the presence of Et 3 N. Thus, both 3-aryl- and 3-alkylisoxazoles, and 3-aryl- and 3-alkylpyrazoles could be prepared from readily available primary alcohols in one pot under transition-metal-free conditions.

Stereospecific copper(II)-catalyzed tandem ring opening/oxidative alkylation of donor-acceptor cyclopropanes with hydrazones: Synthesis of tetrahydropyridazines

Aerobic copper(II)-catalyzed tandem ring opening and oxidative C-H alkylation of donor-acceptor cyclopropanes with bisaryl hydrazones is accomplished to produce tetrahydropyridazines, in which copper(II) plays dual role as a Lewis acid as well as redox catalyst. The reaction is stereospecific, and optically active cyclopropanes can be reacted with high optical purities (89-98% enantiomeric excess). The substrate scope, functional group tolerance, dual role of the copper(II) catalyst, and the use of air as an oxidant are the important practical features. A product bearing a 3-bromoaryl group can be subjected to Pd-catalyzed Suzuki coupling with boronic acid in high yield.

Synthesis of tetrahydropyridazines by a metal-carbene-directed enantioselective vinylogous N-H insertion/Lewis acid-catalyzed diastereoselective Mannich addition

A versatile cascade of reactions, triggered by RhII-catalyzed diazo decomposition followed by a vinylogous N-H insertion/Lewis acid catalyzed Mannich addition, that produces highly substituted 1,2,3,6-tetrahydropyridazines in up to 97% ee with high yield and diastereocontrol has been developed. Copyright