72547-44-5

Basic information

• Product Name: 4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUTYRIC ACID
• Synonyms: BUTTPARK 80\07-72;4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUTYRIC ACID;AKOS BB-3960;AKOS BB/0082;SUCCINIC ACID, 4-METHYLPIPERAZIDE;TIMTEC-BB SBB005752;4-(4-methylpiperazin-1-yl)-4-oxobutanoic acid;4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUTYRIC ACID >98%
• CAS NO: 72547-44-5
• Molecular Formula: C₉H₁₆N₂O₃
• Molecular Weight: 200.23
• Product Categories: piperazines
• Mol File: 72547-44-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 393 °C at 760 mmHg
• Flash Point: 191.5 °C
• Appearance: /
• Density: 1.195 g/cm³
• Vapor Pressure: 2.84E-07mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: 4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUTYRIC ACID(72547-44-5)
• EPA Substance Registry System: 4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUTYRIC ACID(72547-44-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 72547-44-5(Hazardous Substances Data)

Usage

General Description

4-(4-Methyl-piperazin-1-yl)-4-oxo-butyric acid is a chemical compound with a molecular formula C10H17N3O3. It is a derivative of piperazine and is commonly used in the pharmaceutical industry for its potential as a drug intermediate or active pharmaceutical ingredient. It exhibits the properties of a piperazine derivative and a butyric acid derivative, making it potentially useful for various medicinal and therapeutic applications. This chemical compound is of interest to researchers and scientists for its potential pharmacological effects and its role in the development of new drugs for various medical conditions. Further research and study are required to fully understand and harness the potential of 4-(4-Methyl-piperazin-1-yl)-4-oxo-butyric acid in the field of pharmaceuticals.

InChI:InChI=1/C9H16N2O3/c1-10-4-6-11(7-5-10)8(12)2-3-9(13)14/h2-7H2,1H3,(H,13,14)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 108-55-4 glutaric anhydride, 
• 108-30-5 succinic acid anhydride 

Relevant articles and documents

AGONISTS OF THE CHEMOKINE RECEPTOR CXCR3

The present invention relates to agonists of the chemokine receptor CXCR3, methods of their synthesis and uses thereof.

Design, synthesis and biological evaluation of novel pyrenyl derivatives as anticancer agents

Polycyclic aromatic hydrocarbons are widespread in nature with a toxicity range from non-toxic to extremely toxic. A series of pyrenyl derivatives has been synthesized following a four-step strategy where the pyrene nucleus is attached with a basic heterocyclic moiety through a carbon linker. Virtual screening of the physicochemical properties and druggability has been carried out. The cytotoxicity of the compounds (1-8) have been evaluated in vitro against a small panel of human cancer cell lines which includes two liver cancer (HepG2 and Hepa 1-6), two colon cancer (HT-29 and Caco-2) and one each for cervical (HeLa) and breast (MCF-7) cancer cell lines. The IC50 data indicate that compound 6 and 8 are the most effective cytotoxic agents in the present set of pyrenyl derivatives, suggesting that having a 4-carbon linker is more effective than a 5-carbon linker and the presence of amide carbonyl groups in the linker severely reduces the efficacy of the compound. The compounds showed selectivity toward cancer cells at lower doses (51/4M) when compared with the normal hepatocytes. The mechanism of action supports the cell death through apoptosis in a caspase-independent manner without cleavage of poly (ADP-ribose) polymerase (PARP), even though the compounds cause plasma membrane morphological changes. The compounds, whether highly cytotoxic or mildly cytotoxic, localize to the membrane of cells. The compounds with either a piperidine ring (6) or an N-methyl piperazine (8) in the side chain were both capable of circumventing the drug resistance in SKOV3-MDR1-M6/6 ovarian cancer cells overexpressing P-glycoprotein. Qualitative structure-activity relationship has also been studied.

COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS

The invention relates to the use of compounds of formula (I): wherein X is -C(O)-, -C(S)-, -C-NOH, or -CH(R7)- wherein R7 is hydrogen, hydroxy, C1-7alkoxy, -OR8 or -NR8R9 (wherein R8