72563-30-5Relevant academic research and scientific papers
REACTIONS WITH 2-METHYLTHIOPYRIMIDINES, SYNTHESIS OF SOME NEW FUSED PYRIMIDINES
El-Reedy, A. M.,Hussain, S. M.,Ali, A. S.,Abdel-Motty, F.
, p. 231 - 236 (2007/10/02)
4-Chloro-2-methylthio -6-phenylpirimidine-5-carbonitrile (II) reacts with hydrazine hydrate to yield the 2,4-dihydrazino derivative (IIId).Compound IIId reacts with nitrous acid to give ditetrazolopyrimidine (VI) and with carbon disulphide to form pyrazolo-s-triazolopyrimidine (VII).The reaction of II with phenylhydrazine affords directly the pyrazolo-pyrimidinederivative (IV).Also, compound II reacts with anthranilic acid to form 2-methylthio-4-phenyl-6-(o-carboxyphenylamino)pyrimidine-5-carbonitrile IIIe) which can bee cyclised into 1-methylthio-10-oxo-3-phenyl-10-pyrimidoquinazoline-4-carbonitrile (IX) by heating with acetic anhydride.Key words: Methylthiopyrimidine; chloropyrimidine; hydrazinopyrimidine; pyrimidoquinazolinone.
