72568-55-9

Upstream product

• 15802-69-4 2-(4-nitrophenylmethylene)acetoacetic acid ethyl ester 
• 109-77-3 malononitrile 
• 141-97-9 ethyl acetoacetate 
• 2700-23-4 4-Nitrobenzylidenemalononitrile 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 861045-22-9 ethyl 5-cyano-2-methyl-6-oxo-4-(4-nitrophenyl)-1,6-dihydropyridine-3-carboxylate 
• 1605301-92-5 ethyl 6-acetamido-5-carbamoyl-2-methyl-4-(4-nitrophenyl)-4H-pyran-3-carboxylate 
• 1605301-86-7 ethyl 5-(4-nitrophenyl)-2,7-dimethyl-4-oxo-3,5-dihydro-4H-pyrano[2,3-d]pyrimidine-6-carboxylate 
• 94640-15-0 5-cyano-2-methyl-4-(4-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis, ex vivo and in silico studies of 3-cyano-2-pyridone derivatives with vasorelaxant activity

An efficient and simple synthesis of 3-cyano-2-pyridone derivatives (6a-f) through 3,4-dihydropyridin-2-one oxidation process is described. A greener method to synthesize 3,4-dihydropyridin-2-one has also been developed by rearranging 4H-pyran (4a-f) deri

Choline chloride/pentaerythritol: a deep eutectic solvent for the synthesis of pyran and chromene derivatives

Abstract: A novel deep eutectic solvent system was prepared by mixing choline chloride as a hydrogen-bond acceptor with 2,2-bis(hydroxymethyl)propane-1,3-diol (pentaerythritol) as a hydrogen-bond donor. This green solvent was used for the one-pot synthesi

Mesoporous KIT-6 supported ionic liquids as new and highly effective heterogeneous catalysts for three-component synthesis of 2-amino-3-cyano-4H-pyrans

A series of mesoporous KIT-6 supported ionic liquids were prepared and tested as effective and practical catalysts for the synthesis of 2-amino-3-cyano-4H-pyrans. The effects of type of catalysts, catalyst amount, and catalyst stability have also been inv

Cinchonine-driven multi-component domino Knoevenagel–Michael strategy: metal-free synthesis of quinoline-based 4H-pyran and tetrahydro-4H-chromene derivatives

Abstract: Cinchonine-catalyzed simple, expeditious, and efficient protocol for the synthesis of quinoline-based 4H-pyran and tetrahydro-4H-chromenes has been demonstrated via one-pot domino Knoevenagel–Michael cyclocondensation reaction of aromatic aldehyde, active methylene compound and activated C–H acids like alkylacetoacetates/dimedone in ethanol under reflux. This protocol enables a rapid construction of diverse range of 4H-pyran and tetrahydro-4H-chromene derivatives from readily available starting materials. Short reaction time, mild reaction conditions, broad substrate scope, high yields, metal-free approach, and purification without column chromatography are notable features of this methodology.

Ferric Sulfasalazine Sulfa Drug Complex Supported on Cobalt Ferrite Cellulose; Evaluation of Its Activity in MCRs

Abstract: The green and nano catalyst was simply prepared through the reaction of ferric sulfasalazine with nanomaterial CoFe2O4-cellulose as a magnetic biopolymer surface. This novel heterogeneous organometallic catalyst was charact

Preparation and characterization of Ca-modified Co/Al2O3 and its catalytic application in the one-pot synthesis of 4H-pyrans

Abstract: In this research, Co/Ca–Al2O3 composite as a heterogeneous nanocatalyst was synthesized by the co-precipitation method. The effect of Ca addition on the textural properties and the catalytic activity was investigated. The r

Novel biocompatible core/shell Fe3O4?NFC?Co(ii) as a new catalyst in a multicomponent reaction: An efficient and sustainable methodology and novel reusable material for one-pot synthesis of 4: H -pyran and pyranopyrazole in aqueous media

Today, due to the developing need for inexpensive catalysts, recyclable magnetic nanocatalysts immobilized on polysaccharides possess many advantages over classical heterogeneous catalysts. However, cellulose has been an appealing material in catalysis sc

Biocatalytic tandem multicomponent reactions for one-pot synthesis of 2-Amino-4H-Pyran library and in vitro biological evaluation

A simple, effective and ecofriendly biocatalytic method has been developed to construct 2-amino-4H-pyrans via tandem multi-component reaction (MCR) of aldehyde, malononitrile and ethyl acetoacetate in one pot. The catalytic activity of lipases in differen

Synthesis of novel multi-OH functionalized ionic liquid and its application as dual catalyst-solvent for the one-pot synthesis 4H-pyrans

In the present work, triethanolammonium 3-hydroxypropane-1-sulfonate [TEA][HPS] as a novel multi-OH functionalized ionic liquid was synthesized. [TEA][HPS] was characterized by 1HNMR, 13CNMR, FT-IR and elemental analysis. In addition

Synthesis, biological evaluation and molecular docking study of 1,2,3-1H-triazoles having 4H-pyrano[2,3-d]pyrimidine as potential Mycobacterium tuberculosis protein tyrosine phosphatase B inhibitors

Some heterocycles, namely 2-amino-4H-pyran-3-carbonitriles, were synthesized in a three-component reaction from substituted benzaldehydes, malononitrile, and ethyl acetoacetate. These heterocycles have been converted subsequently into 4H-pyrano[2,3-d]pyri