861045-22-9Relevant academic research and scientific papers
Design, synthesis and ex vivo study of the vasorelaxant activity induced by isosteric derivatives of dihydropyridines (NH-O)
Rendón-Vallejo, Priscila,Estrada-Soto, Samuel,Vázquez, Miguel A.,Hernández-Borja, Fernando,Villalobos-Molina, Rafael,Ibarra-Barajas, Maximiliano
, p. 353 - 359 (2016/05/24)
Background: Hypertension is a complex and multifactorial disorder that is an important cause of morbidity and mortality in all around the world; and the rationalized structural modification of drugs represents an important strategy for to develop new anti
Iodine catalyzed simple and efficient synthesis of antiproliferative 2-pyridones
Buduma, Komuraiah,Chinde, Srinivas,Arigari, Niranjana Kumar,Grover, Paramjit,Srinivas,Kotesh Kumar
, p. 2159 - 2163 (2016/04/20)
A simple and efficient method for the selective synthesis of 2-pyrdones from 4H-pyrans using iodine as catalyst and ethanol as solvent was developed. The present method is equally effective for both aromatic and hetero aromatic ring containing 4H-pyrans.
Synthesis, ex vivo and in silico studies of 3-cyano-2-pyridone derivatives with vasorelaxant activity
Hernández, Fernando,Sánchez, Arturo,Rendón-Vallejo, Priscila,Millán-Pacheco, César,Alcaraz, Yolanda,Delgado, Francisco,Vázquez, Miguel A.,Estrada-Soto, Samuel
, p. 669 - 676 (2013/12/04)
An efficient and simple synthesis of 3-cyano-2-pyridone derivatives (6a-f) through 3,4-dihydropyridin-2-one oxidation process is described. A greener method to synthesize 3,4-dihydropyridin-2-one has also been developed by rearranging 4H-pyran (4a-f) deri
