725713-99-5

Upstream product

• 725714-18-1 (+)-[(2R)-1-benzylpiperazin-2-yl]methanol 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 891699-63-1 (E)-3-((S)-1-Benzyl-4-ethoxycarbonylmethyl-piperazin-2-yl)-acrylic acid ethyl ester 
• 891699-79-9 ethyl 2-[(3S)-3-(aminomethyl)-4-benzylpiperazin-1-yl]acetate 
• 891699-23-3 ethyl 2-[(3R)-3-(azidomethyl)-4-benzylpiperazin-1-yl]acetate 

Relevant academic research and scientific papers

Chiral, nonracemic (piperazin-2-yl)methanol derivatives with σ-receptor affinity

Starting with the proteinogenic amino acid (S)-serine a series of chiral nonracemic (piperazin-2-yl)methanols 3 with various N-4 substituents is described. The key step in the synthesis of 3 is the reaction of the chloroacetamide 5 with various primary am